Document Detail


Relationship between mixed venous oxygen saturation and cardiac index in patients with chronic congestive heart failure.
MedLine Citation:
PMID:  2721268     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The use of mixed venous oxygen saturation (SvO2) in patients with chronic congestive heart failure (CHF) has been advocated to analyze the action of therapy on cardiac index (CI). To evaluate the relationship between CI and SvO2, ten CHF patients (mean age 65 years) were studied before and one, two, three, four (T4), six, eight and 24 hours after oral administration of an angiotensin converting enzyme (ACE) inhibitor (perindopril, 4 mg). At T4, a 12 percent increase in CI (p less than 0.01) was associated with a 16 percent decrease in arteriovenous oxygen difference (p less than 0.01), a 13 percent increase in mixed venous oxygen pressure (PvO2) (p less than 0.01), and a 9 percent increase in SvO2 (p less than 0.05) with no significant change in arterial oxygen pressure. There was no correlation between CI and SvO2 (r = 0.22) and between CI and PvO2 (r = 0.23). Individual analyses were performed and patients were divided into two groups based on CI versus SvO2 r value; group 1, n = 6, r greater than 0.65 (0.65-0.90), group 2, n = 4, r less than 0.65 (0.14-0.20). The lack of correlation in group 2 was due to a drug-dependent increase in oxygen consumption (VO2) +18 percent vs -3 percent in group 1 (p less than 0.05) associated with a lack of increase in PvO2 +3 percent vs +14 percent in group 1 (p less than 0.05) despite a similar increase in oxygen availability +19 percent versus +16 percent. It was concluded that (1) a correlation between CI and SvO2 is not found in every patient with CHF; (2) the lack of correlation in four out of our ten patients was due to an associated and significant increase in CI and VO2 in group 2; (3) group 2 patients probably had an important oxygen debt before treatment; (4) SvO2 cannot be used instead of CI to determine the hemodynamic consequences of the use of cardiovascular drugs.
Authors:
C Richard; C Thuillez; M Pezzano; G Bottineau; J F Giudicelli; P Auzepy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chest     Volume:  95     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-07-12     Completed Date:  1989-07-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1289-94     Citation Subset:  AIM; IM    
Affiliation:
Service de Réanimation Médicale, Universite Paris-Sud, Hopital de Bicetre, France.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Aged
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Body Surface Area
Cardiac Output / drug effects*
Female
Heart Failure / blood*,  drug therapy,  physiopathology
Humans
Indoles / therapeutic use
Male
Middle Aged
Oxygen / blood*
Oxygen Consumption
Perindopril
Pulmonary Gas Exchange / drug effects
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Indoles; 7782-44-7/Oxygen; 82834-16-0/Perindopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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