Document Detail

Relationship between micropapillary component and micrometastasis in the regional lymph nodes of patients with stage I lung adenocarcinoma.
MedLine Citation:
PMID:  15569048     Owner:  NLM     Status:  MEDLINE    
AIMS: To determine whether a micropapillary component is a prognostic predictor, with particular reference to nodal micrometastasis, in patients with stage I lung adenocarcinomas. METHODS AND RESULTS: Thirty-five cases with stage I lung adenocarcinomas, obtained from lobectomies or pneumonectomies, and 434 dissected hilar and mediastinal lymph nodes, were retrospectively reviewed. A micropapillary component and nodal micrometastasis were found in 16 (45.7%) and 14 (40%) of the 35 cases, respectively, with nodal micrometastasis in 24 (5.5%) of the 434 lymph nodes, in an immunohistochemical study using an anti-cytokeratin antibody. Ten (62.5%) of the 16 cases with a micropapillary component, and four (21.1%) of the remaining 19 cases, showed nodal micrometastases (P = 0.014). Kaplan-Meier survival curves demonstrated that there was no significant difference between the cases with and without a micropapillary component (P = 0.28). However, the 5 years' survival of the cases with and without nodal micrometastases were 71.4% and 35.7%, respectively (P = 0.03). CONCLUSIONS: A micropapillary component may be a manifestation of aggressive behaviour, as shown by frequent micrometastasis, for stage I lung adenocarcinomas.
M S Roh; J I Lee; P J Choi; Y S Hong
Related Documents :
880048 - Adenocarcinoma in the columnar-lined (barrett) esophagus. case report and review of the...
22997468 - Fascia: a morphological description and classification system based on a literature rev...
7868088 - Mesothelial cell inclusions within mediastinal lymph nodes.
19644538 - A case of recurrent multifocal central giant cell granulomas.
6622328 - Coexisting retroperitoneal and mediastinal fibrosis.
880048 - Adenocarcinoma in the columnar-lined (barrett) esophagus. case report and review of the...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Histopathology     Volume:  45     ISSN:  0309-0167     ISO Abbreviation:  Histopathology     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-30     Completed Date:  2005-04-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7704136     Medline TA:  Histopathology     Country:  England    
Other Details:
Languages:  eng     Pagination:  580-6     Citation Subset:  IM    
Department of Pathology, Dong-A University College of Medicine, Busan, Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenocarcinoma / metabolism,  pathology*
Carcinoma, Papillary / pathology*
Keratins / analysis
Lung Neoplasms / metabolism,  pathology*
Lymph Nodes / pathology*
Lymphatic Metastasis
Middle Aged
Neoplasm Staging
Retrospective Studies
Survival Analysis
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Expression of enamel proteins and LEF1 in adamantinomatous craniopharyngioma: evidence for its odont...
Next Document:  Polymerized alpha-antitrypsin is present on lung vascular endothelium. New insights into the biologi...