| Relationship between metabolic risk factor clustering and cardiovascular mortality stratified by high blood glucose and obesity: NIPPON DATA90, 1990-2000. | |
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MedLine Citation:
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PMID: 17363755 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Metabolic syndrome is diagnosed according to several criteria. Of these, some require glucose intolerance and others require obesity for the diagnosis. We investigated the relationship between metabolic risk factor clustering and cardiovascular disease (CVD) mortality stratified by high blood glucose or obesity. RESEARCH DESIGN AND METHODS: We followed 7,219 Japanese men and women without a history of CVD for 9.6 years. We defined high blood pressure, high blood glucose, high triglycerides, low HDL cholesterol, and obesity as metabolic factors. The multivariate adjusted hazard ratio (HR) for CVD mortality according to the number of clustering metabolic factors was calculated using the Cox proportional hazards model. RESULTS: During follow-up, 173 participants died of CVD. The numbers of metabolic risk factors and CVD mortality were positively correlated (P(trend) = 0.07). The HR was obviously higher among participants with than among those without high blood glucose and clustering of > or =2 other metabolic risk factors (HR 3.67 [95% CI 1.49-9.03]). However, the risk increase was only modest in participants without high blood glucose even if they had > or =2 other metabolic risk factors (1.99 [0.93-4.28]). Conversely, metabolic risk factor clustering was related to CVD mortality irrespective of obesity. CONCLUSIONS: Our findings suggest that glucose tolerance plays an important role in CVD mortality. Because the prevalence of nonobese participants with several metabolic risk factors was quite high and their CVD risk was high, excluding them from the diagnosis of metabolic syndrome because of the absence of obesity might overlook their risk. |
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Authors:
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Aya Kadota; Atsushi Hozawa; Tomonori Okamura; Takashi Kadowak; Koshi Nakmaura; Yoshitaka Murakami; Takehito Hayakawa; Yoshikuni Kita; Akira Okayama; Yasuyuki Nakamura; Atsunori Kashiwagi; Hirotsugu Ueshima; |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2007-03-15 |
Journal Detail:
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Title: Diabetes care Volume: 30 ISSN: 1935-5548 ISO Abbreviation: Diabetes Care Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-05-28 Completed Date: 2007-06-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7805975 Medline TA: Diabetes Care Country: United States |
Other Details:
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Languages: eng Pagination: 1533-8 Citation Subset: IM |
Affiliation:
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Department of Health Science, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu 520-2192, Japan. ayakd@belle.shiga-med.ac.jp. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cardiovascular Diseases / mortality* Female Health Surveys Heart Rate Humans Hyperglycemia / complications, epidemiology* Hypertension / epidemiology Japan / epidemiology Male Middle Aged Obesity / complications, epidemiology* Risk Factors |
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