Document Detail


Relationship between meiotic spindle characteristics in human oocytes and the timing of the first zygotic cleavage after intracytoplasmic sperm injection.
MedLine Citation:
PMID:  21882015     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To investigate the relationship between meiotic spindle characteristics in human oocytes and the timing of the first zygotic cleavage after intracytoplasmic sperm injection (ICSI).
METHODS: Zygotes that had cleaved to two-cell stage by 27 h post-ICSI were classified as early cleaving and the remainder as late cleaving. Meiotic spindle parameters previously imaged using the PolScope were compared between the two groups.
RESULTS: Of 384 embryos, 163 were classed as early cleaving and 221 as late cleaving. The rate of blastocyst formation or pregnancy by Day 2 embryo transfer was significantly higher following early cleavage than after late cleavage (52.4% vs. 24.4% or 32.6% vs. 11.4%). Spindle areas (108.0 vs. 89.8 μm(2)), lengths (14.7 vs. 13.4 μm) and PolScope retardance were also significantly greater in the early cleaving group.
CONCLUSIONS: Meiotic spindle parameters determine the timing of the first zygotic cleavage and are strong indicators of human embryo developmental potential.
Authors:
Hiroyuki Tomari; Kou Honjou; Yumi Nagata; Toshitaka Horiuchi
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Publication Detail:
Type:  Journal Article     Date:  2011-09-01
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  28     ISSN:  1573-7330     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-28     Completed Date:  2012-03-16     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1099-104     Citation Subset:  IM    
Affiliation:
IVF Nagata Clinic, Fukuoka, 810-0001, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blastocyst / cytology
Cleavage Stage, Ovum / cytology
Embryo Transfer
Female
Humans
Meiosis / genetics*
Middle Aged
Mitotic Spindle Apparatus / genetics,  physiology*
Oocytes / cytology*
Polar Bodies / cytology
Pregnancy
Sperm Injections, Intracytoplasmic*
Zygote / cytology*
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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