| Relationship between medicine and stimulated saliva and oral moisture. | |
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MedLine Citation:
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PMID: 19037151 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The aim of this study was to investigate the relationship between medicine and stimulated saliva and oral moisture. METHODS: Fourteen patients with subjective oral dryness and 13 healthy adults were enrolled in this study. Disease, medicine, and medicines that had a side effect of oral dryness were investigated. The Saxon test was performed by chewing a piece of gauze sponge for 2 min. Oral moisture was measured at the lingual and buccal mucosa using an oral moisture checking device. Statistical analysis was performed by the Mann-Whitney U-test and Student t-test. RESULTS: Stimulated saliva and oral moisture did not differ according to the number of diseases. Oral moisture at lingual mucosa was different between a minor medicine group (0-2 types of medicine) (31.3 +/- 1.9%) and a major medicine group (>or=3 types of medicine) (29.5 +/- 2.2%) (p = 0.05). Oral moisture differed between a group not taking any medicine that had a side effect of oral dryness (31.2 +/- 1.8% at lingual mucosa and 33.8 +/- 1.4% at buccal mucosa) and a group taking such medicine (29.3 +/- 2.3% at lingual mucosa and 32.4 +/- 1.8% at buccal mucosa) (p < 0.05). CONCLUSION: The results of this study showed that oral moisture tended to decrease in the subjects who took many types of medicine or who took medicine that had a side effect of oral dryness. The medicine did not influence the amount of stimulated saliva. Therefore, it was suggested that medicine could influence the moisture of the oral mucosa. |
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Authors:
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Fumi Takahashi; Mutsumi Takahashi; Shuji Toya; Osami Morita |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nihon Hotetsu Shika Gakkai zasshi Volume: 52 ISSN: 0389-5386 ISO Abbreviation: Nihon Hotetsu Shika Gakkai Zasshi Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-11-27 Completed Date: 2009-03-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7505724 Medline TA: Nihon Hotetsu Shika Gakkai Zasshi Country: Japan |
Other Details:
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Languages: eng Pagination: 537-42 Citation Subset: D; IM |
Affiliation:
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Department of Complete Denture, The Nippon Dental University School of Life Dentistry at Niigata, Japan. fumichan@ngt.ndu.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Drug Therapy Female Humans Male Middle Aged Salivation / drug effects*, physiology* Xerostomia / physiopathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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