Document Detail

Relationship between maternal arterial wave reflection, microvascular function and fetal growth in normal pregnancy.
MedLine Citation:
PMID:  21044215     Owner:  NLM     Status:  In-Process    
OBJECTIVE: In 50 normotensive pregnancies, we examined the relationship between fetal growth, arterial wave reflection, and microvascular function at 22, 34 weeks gestation, and six weeks postpartum.
METHODS: Arterial wave reflection was determined by measuring augmentation index (AIx). Changes in skin microcirculation to acetylcholine (ACh) and sodium nitroprusside (SNP) were assessed using laser Doppler imaging.
RESULTS: At 22 weeks, birth weight centile correlated with AIx adjusted for maternal age, MAP, heart rate and timing of reflected wave (r = -0.363, p = 0.012), and with ACh responses (r = 0.317, p = 0.022). ACh responses correlated with adjusted AIx (r = -0.420, p = 0.003). At 34 weeks, birth weight centile correlated with the adjusted AIx (r = -0.301, p = 0.048). ACh responses were borderline correlated with adjusted AIx (r = -0.323, p = 0.074). At six weeks postpartum, no significant correlations were found between birth weight centile, AIx, and ACh responses. SNP responses did not correlate with AIx or birth weight centile at any time point.
CONCLUSION: During normal pregnancy, changes in vascular function might reflect important adaptations that are required to facilitate normal fetal growth. This was highlighted in the present study by the findings of a positive correlation between birth weight and endothelial function and a negative correlation between birth weight and arterial wave reflection.
Faisel Khan; Gary Mires; Maureen Macleod; Jill J F Belch
Related Documents :
21188495 - Assisted reproduction in a patient with klippel-trenaunay syndrome: management of throm...
7198425 - Natural selection associated with birth weight. i. selection intensity and selective de...
17636585 - Withdrawn: energy/protein restriction for high weight-for-height or weight gain during ...
16374225 - Diet during pregnancy and levels of maternal pregnancy hormones in relation to the risk...
16517315 - In vitro effects of 3 common arthroscopic instruments on articular cartilage.
17710575 - New-onset hypertension in late pregnancy and fetal growth: different associations betwe...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Microcirculation (New York, N.Y. : 1994)     Volume:  17     ISSN:  1549-8719     ISO Abbreviation:  Microcirculation     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9434935     Medline TA:  Microcirculation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  608-14     Citation Subset:  IM    
Copyright Information:
© 2010 John Wiley & Sons Ltd.
Vascular and Inflammatory Diseases Research Unit, The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Grant Support
PG2000131//British Heart Foundation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Contribution of adenosine A(2A) and A(2B) receptors to ischemic coronary dilation: role of K(V) and ...
Next Document:  Blood flow and cell-free layer in microvessels.