Document Detail


Relationship between maternal arterial wave reflection, microvascular function and fetal growth in normal pregnancy.
MedLine Citation:
PMID:  21044215     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
OBJECTIVE: In 50 normotensive pregnancies, we examined the relationship between fetal growth, arterial wave reflection, and microvascular function at 22, 34 weeks gestation, and six weeks postpartum.
METHODS: Arterial wave reflection was determined by measuring augmentation index (AIx). Changes in skin microcirculation to acetylcholine (ACh) and sodium nitroprusside (SNP) were assessed using laser Doppler imaging.
RESULTS: At 22 weeks, birth weight centile correlated with AIx adjusted for maternal age, MAP, heart rate and timing of reflected wave (r = -0.363, p = 0.012), and with ACh responses (r = 0.317, p = 0.022). ACh responses correlated with adjusted AIx (r = -0.420, p = 0.003). At 34 weeks, birth weight centile correlated with the adjusted AIx (r = -0.301, p = 0.048). ACh responses were borderline correlated with adjusted AIx (r = -0.323, p = 0.074). At six weeks postpartum, no significant correlations were found between birth weight centile, AIx, and ACh responses. SNP responses did not correlate with AIx or birth weight centile at any time point.
CONCLUSION: During normal pregnancy, changes in vascular function might reflect important adaptations that are required to facilitate normal fetal growth. This was highlighted in the present study by the findings of a positive correlation between birth weight and endothelial function and a negative correlation between birth weight and arterial wave reflection.
Authors:
Faisel Khan; Gary Mires; Maureen Macleod; Jill J F Belch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Microcirculation (New York, N.Y. : 1994)     Volume:  17     ISSN:  1549-8719     ISO Abbreviation:  Microcirculation     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9434935     Medline TA:  Microcirculation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  608-14     Citation Subset:  IM    
Copyright Information:
© 2010 John Wiley & Sons Ltd.
Affiliation:
Vascular and Inflammatory Diseases Research Unit, The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK. f.khan@dundee.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
PG2000131//British Heart Foundation

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