Document Detail


Relationship between mammographic screening intervals and size and histology of ductal carcinoma in situ.
MedLine Citation:
PMID:  9930774     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The objective of this study was to determine how the length of time between mammographic screenings is related to the size, grade, and histology of mammographically detected ductal carcinoma in situ (DCIS). MATERIALS AND METHODS: We retrospectively reviewed 166 consecutive mammograms of women evaluated for DCIS with (n = 24) and without (n = 142) microinvasion. The size of the DCIS was determined by the maximum diameter as measured on the mammogram. After pathologic analysis, DCIS was classified by histologic architecture, nuclear grade, presence of microinvasion, and presence of multifocality. Four screening intervals were defined: annual (6-17 months), biennial (18-29 months), triennial (> or = 30 months), and first time. Patients were grouped according to screening intervals. The average age of all groups was 55 years. RESULTS: The annual group (mean size of DCIS, 1.69 cm) had significantly smaller DCIS than did the biennial (mean size, 2.27 cm), triennial (mean size, 3.49 cm), or first time groups (mean size, 3.29 cm) (p = .003). Comedo histology was more frequently observed in patients screened biennially (73.7%) than in those screened annually (46.8%) (p = .05). High-grade nuclear histology was more commonly seen in the biennial (76.3%) than in the annual (48.1%) screening group (p = .008). We found no significant correlation between screening interval and the incidence of microinvasion and multifocality. CONCLUSION: Small, low-grade noncomedo DCIS was more common in the annual mammographic screening group than in the biennial screening group. A direct relationship was found between DCIS size and length of screening interval: DCIS detected at annual screening was smaller than that found at biennial screening, which in turn was smaller than DCIS revealed at triennial screening. This study provides inferential support for annual screening mammography for DCIS detection and management.
Authors:
K L Carlson; M A Helvie; M A Roubidoux; C G Kleer; H A Oberman; T E Wilson; E W Pollak; A B Rochester
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  AJR. American journal of roentgenology     Volume:  172     ISSN:  0361-803X     ISO Abbreviation:  AJR Am J Roentgenol     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-02-18     Completed Date:  1999-02-18     Revised Date:  2008-02-15    
Medline Journal Info:
Nlm Unique ID:  7708173     Medline TA:  AJR Am J Roentgenol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  313-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Radiology, University of Michigan Hospitals, Ann Arbor 48109-0326, USA.
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MeSH Terms
Descriptor/Qualifier:
Breast / pathology
Breast Neoplasms / pathology*,  radiography
Carcinoma in Situ / pathology*,  radiography
Carcinoma, Ductal, Breast / pathology*,  radiography
Case-Control Studies
Female
Humans
Mammography / statistics & numerical data
Mass Screening / statistics & numerical data
Middle Aged
Retrospective Studies
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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