| Relationship between magnetic resonance imaging and molecular pathology in patients with glioblastoma multiforme. | |
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MedLine Citation:
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PMID: 22040408 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Glioblastoma multiforme (GBM) is the most common and lethal primary brain tumor in adults. Magnetic resonance imaging (MRI) is routinely used in the diagnosis, characterization and clinical management of GBM. The diagnosis and treatment of GBM is largely guided by histopathology and immunohistochemistry. This study aimed to identify the relationship between magnetic resonance features and molecular pathology of GBM. METHODS: MRI images of 43 glioblastoma patients were collected. Four imaging features, degree of edema, contrast tumor enhanced/T2 ratio, multiple lesions and tumor across the midline, were selected to identify their relationship with P53, Ki-67 and O(6)-methylguanine-DNA methltransferase (MGMT) expression in patients with GBM. The relationship between imaging features and molecular pathology was studied by chi-square test using the software SPSS 13.0. RESULTS: High expression of P53 was found correlated with low contrast tumor enhanced/T2 ratio, low expression of Ki-67 was correlated with multiple lesions and high expression of KI-67 may be related with tumor across the midline, low expression of MGMT was correlated with edema. CONCLUSION: Some MRI features such as the degree of edema, contrast tumor enhanced/T2 ratio, multiple lesions and tumor acrossing the midline are correlated with P53, Ki-67 and MGMT of GBM. |
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Authors:
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Wen-Bin Li; Kai Tang; Wei Zhang; Wei Yan; Gang You; Shao-Wu Li; Long Zhang; Yan-Jie Huang; Tao Jiang |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chinese medical journal Volume: 124 ISSN: 0366-6999 ISO Abbreviation: Chin. Med. J. Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-11-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7513795 Medline TA: Chin Med J (Engl) Country: China |
Other Details:
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Languages: eng Pagination: 2589-92 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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