| Relationship between lymphangiogenesis and exudates during the wound-healing process of mouse skin full-thickness wound. | |
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MedLine Citation:
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PMID: 19614925 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We considered the relationship among exudate, wound area, angiogenesis, lymphangiogenesis, and reepithelialization during wound healing. Full-thickness wounds were made on the dorsum of mice. The weight of exudate absorbed into the dressing as well as the wound area was determined daily. Sections of the wounds were stained with anti-LYVE-1 and CD31 antibodies. Indian ink was injected into the wound for observing the movement of the exudate on days 3, 5, and 7 after wounding. New epithelium completely covered the wound on day 11. The quantity of exudate peaked on day 1, and then rapidly decreased until it was undetectable on day 11. Most of the Indian ink injected into the wound was retained within the wound and did not flow into the surrounding tissue. New blood vessels showed a uniform distribution in the granulation tissue on day 5. New lymphatics appeared in the granulation tissue approximately 2 days later than the blood vessels and they were distributed toward the center of the granulation tissue on day 11. Thus, reduction of exudate from the wound appears to be related to blood vessels, not lymphatics. However, increasing lymphatics may play a role in the late phase of the wound-healing process. |
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Authors:
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Kimi Shimamura; Toshio Nakatani; Aiko Ueda; Junko Sugama; Mayumi Okuwa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society Volume: 17 ISSN: 1524-475X ISO Abbreviation: Wound Repair Regen Publication Date: 2009 Jul-Aug |
Date Detail:
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Created Date: 2009-07-20 Completed Date: 2009-09-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9310939 Medline TA: Wound Repair Regen Country: United States |
Other Details:
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Languages: eng Pagination: 598-605 Citation Subset: IM |
Affiliation:
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Department of Clinical Nursing, Graduate Course of Nursing Science, Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, Kanazawa 9200942, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Exudates and Transudates / physiology* Lymphangiogenesis / physiology* Male Mice Mice, Inbred C57BL Skin / injuries*, pathology Wound Healing / physiology* |
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