| Relationship between lymph node sinuses with blood and lymphatic metastasis of gastric cancer. | |
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MedLine Citation:
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PMID: 12508348 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To elucidate the relationship between lymph node sinuses with blood and lymphatic metastasis of gastric cancer. METHODS: Routine autopsy was carried out in the randomly selected 102 patients (among them 100 patients died of various diseases, and 2 patients died of non-diseased reasons), their superficial lymph nodes locating in bilateral necks (include supraclavicle), axilla, inguina, thorax, and abdomen were sampled. Haematoxylin-Eosin staining was performed on 10 % formalin-fixed and paraffin-embedded lymph node tissue sections (5 um). The histological patterns of the lymph sinuses containing blood were observed under light microscope. The expression of CD31, a marker for endothelial cell, was detected both in blood and non-blood containing lymph node sinuses with the method of immunohistochemistry. RESULTS: Among the 1 322 lymph nodes sampled from the autopsies of 100 diseased cases, lymph node sinuses containing blood were found in 809 lymph nodes sampled from 91 cases, but couldn't be seen in the lymph nodes sampled from the non-diseased cases. According to histology, we divided the blood containing lymph node sinuses into five categories: vascular-opening sinus, blood-deficient sinus, erythrophago-sinus, blood-abundant sinus, vascular-formative sinus. Immunohistochemical findings showed that the expression of CD31 was strongly positive in vascular-formative sinuses and some vascular-opening sinuses while it was faint in blood-deficient sinuses, erythrophago-sinuses and some vascular-opening sinuses. It was almost negative in blood-abundant sinus and non-blood containing sinus. CONCLUSION: In the state of disease, the phenomenon of blood present in the lymph sinus is not uncommon. Blood could possibly enter into the lymph sinuses through the lymphaticovenous communications between the veins and the sinuses in the node. Lymph circulation and the blood circulation could communicate with each other in the lymph node sinuses. The skipping and distal lymphatic metastasis of gastric cancer may have some connection with the blood containing lymph node sinuses. |
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Authors:
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Tong Yin; Xiao-Long Ji; Min-Shi Shen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 9 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2002-12-31 Completed Date: 2003-06-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 40-3 Citation Subset: IM |
Affiliation:
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General Hospital of PLA, 28 Fu Xing Road, Beijing 100853, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Antigens, CD31 / analysis Blood Cells / cytology Child Child, Preschool Female Humans Infant Lymph Nodes / pathology* Lymphatic Metastasis* Male Middle Aged Stomach Neoplasms / pathology* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD31 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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