Document Detail

Relationship between lower urinary tract abnormalities and disease-related parameters in multiple sclerosis.
MedLine Citation:
PMID:  7539859     Owner:  NLM     Status:  MEDLINE    
Multiple sclerosis affects the lower urinary tract in many patients. The relationship between lower urinary tract abnormalities and disease-related parameters of multiple sclerosis is not well described. We screened urologically and neurologically 212 patients according to a standard protocol. Micturition complaints were noted in 52% of the patients and urodynamic abnormalities were found in 64%. A statistical correlation was found between detrusor hyperactivity and detrusor hypoactivity with disease-related parameters, that is disease duration, disability status, myelin basic protein concentration in the cerebrospinal fluid and neurophysiological investigations. No relationship was found between detrusor hypersensibility or detrusor hyposensibility and the aforementioned disease-related parameters. In 1 patient upper urinary tract abnormalities were noted in combination with urodynamic abnormalities. We conclude that lower urinary tract abnormalities can be found in every patient with multiple sclerosis unrelated to the state of the disease. Severe upper urinary tract abnormalities are rare.
E L Koldewijn; O R Hommes; W A Lemmens; F M Debruyne; P E van Kerrebroeck
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of urology     Volume:  154     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-07-07     Completed Date:  1995-07-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  169-73     Citation Subset:  AIM; IM    
Department of Urology, University Hospital Nijmegen, The Netherlands.
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MeSH Terms
Anal Canal / physiopathology
Evoked Potentials, Somatosensory / physiology
Middle Aged
Multiple Sclerosis / cerebrospinal fluid,  complications*,  physiopathology
Myelin Basic Proteins / cerebrospinal fluid
Reaction Time
Reflex / physiology
Sex Characteristics
Urethra / physiopathology
Urinary Bladder / physiopathology
Urinary Bladder Diseases / complications*,  physiopathology
Urinary Incontinence / complications,  physiopathology
Urination Disorders / complications*,  physiopathology
Reg. No./Substance:
0/Myelin Basic Proteins
Comment In:
J Urol. 1995 Jul;154(1):184-5   [PMID:  7776418 ]

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