Document Detail

Relationship between leptin and all-cause and cardiovascular mortality in chronic hemodialysis patients.
MedLine Citation:
PMID:  21461015     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We aimed to evaluate the relationship between serum leptin and the leptin/body mass index (BMI) ratio with prevalent cardiovascular disease (CVD), and their influence on all-cause and CVD-related mortality in patients on hemodialysis (HD).
METHODS: 118 stable HD patients (50 women, median [interquartile range] age, 65.1 [54.7-72.2] years) were studied. All patients had baseline measurement of serum leptin concentrations. Relationships between leptin and all-cause and CVD mortality were studied by means of survival analysis and Cox regression analysis.
RESULTS: The leptin/BMI ratio was similar in patients with and without CVD at baseline (0.65 [0.29-2.23] vs. 0.68 [0.29-1.49] ng·m2/ml·kg, respectively, NS). Multiple logistic regression analysis showed that there was not an independent association between leptin/BMI ratio and prevalent CVD. During the follow-up time, 52 (44.1%) patients died. CVD was the cause of death in 27 out of 52 (51.9%) deceased patients. Survival analysis and Cox proportional multivariate regression analysis showed that there were no significant relationships between leptin levels or the leptin/BMI ratio and all-cause and CVD-related mortality.
CONCLUSION: These results do not support that, in stable HD patients, serum leptin concentrations and the leptin/BMI ratio are related with prevalent CVD. Leptin/BMI ratio seems not to be a risk factor for mortality in these patients.
Juan José Díez; Maurizio Bossola; María José Fernández-Reyes; Enrico Di Stasio; Luigi Tazza; Giovanna Luciani; Rosa Codoceo; Pedro Iglesias; Astrid Rodríguez; Elena González; Rafael Selgas
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nefrología : publicación oficial de la Sociedad Española Nefrologia     Volume:  31     ISSN:  1989-2284     ISO Abbreviation:  Nefrologia     Publication Date:  2011  
Date Detail:
Created Date:  2011-04-04     Completed Date:  2011-08-23     Revised Date:  2011-11-03    
Medline Journal Info:
Nlm Unique ID:  8301215     Medline TA:  Nefrologia     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  206-12     Citation Subset:  IM    
Servicio de Endocrinología, Hospital Ramón y Cajal, Madrid.
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MeSH Terms
Body Mass Index
Cardiovascular Diseases / blood*,  mortality
Cause of Death
Cohort Studies
Follow-Up Studies
Italy / epidemiology
Kaplan-Meier Estimate
Kidney Failure, Chronic / blood*,  mortality,  therapy
Leptin / blood*
Middle Aged
Obesity / blood,  epidemiology
Proportional Hazards Models
Prospective Studies
Renal Dialysis* / statistics & numerical data
Risk Factors
Spain / epidemiology
Statistics, Nonparametric
Reg. No./Substance:

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