| Relationship between leptin and all-cause and cardiovascular mortality in chronic hemodialysis patients. | |
| | |
MedLine Citation:
|
PMID: 21461015 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: We aimed to evaluate the relationship between serum leptin and the leptin/body mass index (BMI) ratio with prevalent cardiovascular disease (CVD), and their influence on all-cause and CVD-related mortality in patients on hemodialysis (HD). METHODS: 118 stable HD patients (50 women, median [interquartile range] age, 65.1 [54.7-72.2] years) were studied. All patients had baseline measurement of serum leptin concentrations. Relationships between leptin and all-cause and CVD mortality were studied by means of survival analysis and Cox regression analysis. RESULTS: The leptin/BMI ratio was similar in patients with and without CVD at baseline (0.65 [0.29-2.23] vs. 0.68 [0.29-1.49] ng·m2/ml·kg, respectively, NS). Multiple logistic regression analysis showed that there was not an independent association between leptin/BMI ratio and prevalent CVD. During the follow-up time, 52 (44.1%) patients died. CVD was the cause of death in 27 out of 52 (51.9%) deceased patients. Survival analysis and Cox proportional multivariate regression analysis showed that there were no significant relationships between leptin levels or the leptin/BMI ratio and all-cause and CVD-related mortality. CONCLUSION: These results do not support that, in stable HD patients, serum leptin concentrations and the leptin/BMI ratio are related with prevalent CVD. Leptin/BMI ratio seems not to be a risk factor for mortality in these patients. |
| | |
Authors:
|
Juan José Díez; Maurizio Bossola; María José Fernández-Reyes; Enrico Di Stasio; Luigi Tazza; Giovanna Luciani; Rosa Codoceo; Pedro Iglesias; Astrid Rodríguez; Elena González; Rafael Selgas |
Related Documents
:
|
18283395 - Need for extensive diagnostic work-up for patients with lacunar stroke. 11546905 - Predictors of fatal brain edema in massive hemispheric ischemic stroke. 19826585 - Cerebrovascular manifestations and alteration of coagulation profile in scorpion sting:... 17895145 - Poststroke seizures in stroke rehabilitation patients. 22232615 - Variable initial swing side and prolonged double limb support represent abnormalities o... 9855265 - Liver function in cirrhotic patients in the euthyroid versus the hypothyroid state. |
Publication Detail:
|
Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Nefrología : publicación oficial de la Sociedad Española Nefrologia Volume: 31 ISSN: 1989-2284 ISO Abbreviation: Nefrologia Publication Date: 2011 |
Date Detail:
|
Created Date: 2011-04-04 Completed Date: 2011-08-23 Revised Date: 2011-11-03 |
Medline Journal Info:
|
Nlm Unique ID: 8301215 Medline TA: Nefrologia Country: Spain |
Other Details:
|
Languages: eng Pagination: 206-12 Citation Subset: IM |
Affiliation:
|
Servicio de Endocrinología, Hospital Ramón y Cajal, Madrid. jdiez.hrc@salud.madrid.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Body Mass Index Cardiovascular Diseases / blood*, mortality Cause of Death Cohort Studies Comorbidity Female Follow-Up Studies Humans Italy / epidemiology Kaplan-Meier Estimate Kidney Failure, Chronic / blood*, mortality, therapy Leptin / blood* Male Middle Aged Mortality* Obesity / blood, epidemiology Proportional Hazards Models Prospective Studies Renal Dialysis* / statistics & numerical data Risk Factors Spain / epidemiology Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
|
0/Leptin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: [Dispositional optimism in patients on chronic haemodialysis and its possible influence on their cli...
Next Document: [Pleuroperitoneal communication in patients on peritoneal dialysis. One hospital's experience and a ...