Document Detail


Relationship between left ventricular hypertrophy, hypertensive retinopathy, microalbuminuria and echocardiographic modalities in newly diagnosed hypertensive patients.
MedLine Citation:
PMID:  20111906     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Longitudinal myocardial function (LMF) may be impaired while systolic function is still normal. We investigated relationship between LMF and hypertensive organ damage in newly diagnosed stage I hypertensive patients. A total of 57 patient with never treated stage I hypertension and 48 matched healthy control subject were enrolled in the study. Conventional 2-D, Doppler and tissue wave Doppler imaging (TDI) echocardiography were used. LMF was evaluated by the septal and lateral strain (S) and strain rate (SR) measurements. Hypertensive complications were evaluated by the urine microalbumin levels and retinal examination. A multivariate regression analysis was perfomed to assess the relation between the variables. Ejection fraction, mid-wall fractional shortenning, systolic movement rates (TDs) in TDI were similar both in hypertensive and control groups. In patients with left ventricular hypertrophy, septal TDs (7.29 +/- 1.28 vs. 8.06 +/- 1.19 cm, P = 0.03), lateral TDs (8.46 +/- 1.83 vs. 9.87 +/- 2.42 cm, P = 0.01) and lateral S (-13.02 +/- 7.83 vs. -18.86 +/- 8.60%, P = 0.01) values were significantly lower. Septal S (-13.67 +/- 3.52 vs. -19.09 +/- 5.96%, P < 0.01) and SR (-0.83 +/- 0.29 vs. -1.22 +/- 0.28 1/S, P < 0.01) were significantly decreased in hypertensive patients with microalbuminuria. Septal S value was also significantly decreased in patients with retinopathy (-14.76 +/- 5.55 vs. -20.20 +/- 5.44%, P = 0.01). Multivariate analysis showed that only septal and lateral S values were independent factors for the retinopathy and left ventricular hypertrophy, respectively. In hypertensive patients, LMF established by the measurement of S and SR, might be impaired and also related with end organ damage while global circumferential function is preserved.
Authors:
Ahmet Kaya Bilge; Dursun Atilgan; Imran Onur; Burak Pamukcu; Mustafa Ozcan; Kâmil Adalet
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Publication Detail:
Type:  Journal Article     Date:  2010-01-29
Journal Detail:
Title:  The international journal of cardiovascular imaging     Volume:  26     ISSN:  1875-8312     ISO Abbreviation:  Int J Cardiovasc Imaging     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-12     Completed Date:  2010-07-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100969716     Medline TA:  Int J Cardiovasc Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  405-12     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Istanbul Faculty of Medicine, Istanbul University, 34390, Capa, Istanbul, Turkey. ahmetkayabilge@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Albuminuria / diagnosis,  etiology*
Case-Control Studies
Chi-Square Distribution
Diagnostic Techniques, Ophthalmological
Echocardiography, Doppler*
Echocardiography, Doppler, Pulsed
Female
Humans
Hypertension / complications*,  ultrasonography
Hypertrophy, Left Ventricular / etiology,  physiopathology,  ultrasonography*
Logistic Models
Male
Middle Aged
Nephelometry and Turbidimetry
Predictive Value of Tests
Retinal Diseases / diagnosis,  etiology*
Risk Assessment
Risk Factors
Ventricular Function, Left

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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