Document Detail

Relationship between late potentials and myocardial viability assessed by dobutamine echocardiography in the early postinfarction period.
MedLine Citation:
PMID:  12004264     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In the postmyocardial infarction period, late potentials (LPs) are a sensitive marker for the occurrence of sustained ventricular tachycardia and ventricular fibrillation. The relationship between positive signal-averaged electrocardiogram (SAECG) and myocardial viability remains controversial. The aim of the present study was to assess prospectively the possible relationship between LPs and myocardial viability detected by dobutamine stress echocardiography (DSE) in the early period after myocardial infarction (AMI), before hospital discharge. DESIGN: Ninety-nine patients with AMI were included prospectively in the study. The mean age was 58 +/- 11 years, 17 were women and 82 were men. All patients had SAEG and DSE, and 94 had coronary angiography before hospital discharge. RESULTS: In the overall population, presence of viability was demonstrated in fewer patients with LPs [37 of 70 (52%)] than absence of viability [18 of 29 (62%)] but the difference did not reach statistical significance. In the subgroup of patients with left ventricular ejection fraction (LVEF) lower than 40%, at higher risk of arrhythmias, the presence of viability was associated with the absence of LPs: 80% of the patients without LPs had viability by DSE (P < 0.01) and only 35% of patients with LPs had viability by DSE (not significant). CONCLUSIONS: In patients with an acute myocardial infarction and with low ejection fraction (<40%), the absence of LPs is related to the presence of viable myocardium as assessed by DSE early after the acute event. These data also suggest that myocardial viability is not the substrate for LPs in this population.
Bernard Cosyns; Elif Akseki; Guy Van Camp; Danny Schoors; Isabelle Liebens; Danièle Plein; Jean-Luc Vandenbossche; Philippe Franken
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Coronary artery disease     Volume:  13     ISSN:  0954-6928     ISO Abbreviation:  Coron. Artery Dis.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-05-10     Completed Date:  2002-05-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9011445     Medline TA:  Coron Artery Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  119-23     Citation Subset:  IM    
Cardiology Department, Academisch Ziekenhuis, Vrije Universiteit Brussel, Belgium.
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MeSH Terms
Adrenergic beta-Agonists / diagnostic use*
Dobutamine / diagnostic use*
Echocardiography, Stress
Middle Aged
Myocardial Infarction / physiopathology,  ultrasonography*
Prospective Studies
Risk Assessment
Stroke Volume
Reg. No./Substance:
0/Adrenergic beta-Agonists; 34368-04-2/Dobutamine

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