| Relationship between intestinal gas and the development of right colonic diverticula. | |
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MedLine Citation:
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PMID: 21103424 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUNDS/AIMS: High intraluminal pressure has been reported to cause left colonic diverticula. However, the pathophysiology of right colonic diverticula is still unclear. Methane gas has been reported to delay small intestinal transit and to increase intraluminal pressure. The aim of this study was to evaluate the relationship between right colonic diverticula and intestinal gas produced by enteric bacteria. METHODS: Lactulose breath tests were performed in 30 patients who were diagnosed with right colonic diverticula via colonoscopy. The control group consisted of 30 healthy adults with no specific symptoms or medical histories. A hydrogen or methane producer was defined in 2 ways: either one that exhibited a breath hydrogen level ≥ 20 ppm (methane ≥ 10 ppm) baseline or one that exhibited an increase in breath hydrogen ≥ 20 ppm (methane ≥ 10 ppm) above baseline within the first 90 minutes of the test. RESULTS: The lactulose breath test (LBT) positivity in the diverticular group and the control group were 40.0% and 33.3%, respectively, without a statistically significant difference. The concentrations of methane and hydrogen gas measured by LBT increased over time, but there was no significant difference between the control and the diverticular groups. CONCLUSIONS: There was no significant relationship between right colonic diverticula and intestinal gases produced by enteric bacteria. However, time-dependent formation of diverticula should be taken into consideration, therefore long-term, large-scale follow-up studies may reveal further pathogenesis of right colonic diverticulosis. |
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Authors:
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Sung-Ill Jang; Jie-Hyun Kim; Young Hoon Youn; Hyojin Park; Sang In Lee; Jeffrey L Conklin |
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Publication Detail:
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Type: Journal Article Date: 2010-10-30 |
Journal Detail:
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Title: Journal of neurogastroenterology and motility Volume: 16 ISSN: 2093-0887 ISO Abbreviation: J Neurogastroenterol Motil Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101530189 Medline TA: J Neurogastroenterol Motil Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 418-23 Citation Subset: - |
Affiliation:
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Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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