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Relationship between interpregnancy interval and birth defects in Washington State.
MedLine Citation:
PMID:  21546941     Owner:  NLM     Status:  Publisher    
Objective:Interpregnancy interval (IPI) influences numerous adverse perinatal outcomes. IPI's impact on birth defects is unclear.Study Design:We conducted a population-based case-control study, using 1998 to 2008 administrative data from Washington State. A total of 10 772 cases, women whose second of two births resulted in an infant with a birth defect, were compared with 32 310 controls, women whose second of two births did not result in an infant with a birth defect.Result:Compared with mothers with an IPI between 18 to 23 months, those with an IPI <6 months or 60 months had elevated risks of delivering an infant with a birth defect (odds ratio=1.15, 95% confidence interval: 1.03 to 1.28, and odds ratio=1.15, 95% confidence interval: 1.04 to 1.26, respectively).Conclusion:We observed a J-shaped relationship between IPI and risk of having an infant with a birth defect. As this is one of the first studies to evaluate this association, confirmatory studies are needed.Journal of Perinatology advance online publication, 5 May 2011; doi:10.1038/jp.2011.49.
S Kwon; M Lazo-Escalante; M V Villaran; C I Li
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-05
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  -     ISSN:  1476-5543     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Surgery, University of Washington, Seattle, WA, USA.
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