Document Detail


Relationship between insulin-like growth factor-1 system and exercise tolerance in patients with intermittent claudication.
MedLine Citation:
PMID:  19506539     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
AIM: Insulin-like growth factor-1 (IGF-1) plays an important role in exercise physiology. We aimed the present study at assessing whether IGF-1 system and its changes with exercise are related to walking capacity in intermittent claudication (IC). METHODS: In 45 IC patients, blood samples for the measurement of IGF-1, IGF binding protein-3 (IGFBP-3), and acid labile subunit (ALS) were taken at rest and immediately after a treadmill exercise performed until initial claudication distance (ICD), i.e. until the occurrence of claudication pain in the affected limb. Control group consisted of 45 age- and sex-matched subjects without previous myocardial infarction or stroke. RESULTS: When IC patients were divided into two groups according to ICD value, ANOVA showed significant group differences for IGFBP-3 and ALS. Indeed, resting levels of IGFBP-3 were 3537+/-109 mg/L in controls, moderately lower (3399+/-204 mg/L) in IC patients with ICD median, and markedly lower (2580+/-196 mg/L) in those with ICD<median. ANOVA showed a significant difference between the three groups (F=9.42, P=0.001). Corresponding values for ALS were 13.4+/-0.9 mg/L, 10.0+/-1.2 mg/L, and 5.9+/-0.7 mg/L (F=14.21, P=0.001). A similar trend was observed for IGF-1 (F=2.85, P=0.063). Also the subdivision of the IC population according to ankle/brachial index median value showed that values of IGFBP-3 and ALS resulted progressively lower as the severity of the disease increased (F=4.71, P=0.011 for IGFBP-3, and F=12.04, P=0.001, for ALS). Exercise significantly increased serum levels of the three components of the IGF-1 system. Furthermore, ICD showed a direct correlation with exercise-induced changes in serum levels of IGF-1 (r=0.465, P<0.001), and ALS (r=0.624, P<0.001). At multivariate analysis, ICD remained associated with both IGF-1 (b-coefficient=0.513, P<0.001), and ALS (b-coefficient=0.645, P<0.001), after correction for confounding factors. CONCLUSIONS: Impaired IGF-1 system is implicated in the complex mechanism responsible for reduced exercise tolerance in IC. Furthermore, this finding suggests that affected individuals could represent a target population for interventions to rise IGF-1 levels.
Authors:
E Laurenzano; G Brevetti; S Lanero; L Brevetti; A Colao; M Chiariello
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International angiology : a journal of the International Union of Angiology     Volume:  28     ISSN:  1827-1839     ISO Abbreviation:  Int Angiol     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8402693     Medline TA:  Int Angiol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  202-8     Citation Subset:  IM    
Affiliation:
Departments of Clinical Medicine and Cardiovascular and Immunological Sciences, University of Naples ''Federico II'', Naples, Italy brevetti@unina.it.
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