Document Detail


Relationship between insulin-like growth factors (IGF-I and IGF-II), IGF-binding proteins (IGFBP-3, IGFBP-2), leptin and anthropometric parameters (height, body mass index) during antileukaemic treatment in children.
MedLine Citation:
PMID:  16358968     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The aim of the study was to estimate the anthropometric parameters and their relationship to serum levels of IGF-I, IGF-II, IGFBP-3, IGFBP-2 and leptin before and during intensive antineoplastic treatment for acute lymphoblastic leukaemia in children. MATERIAL AND METHODS: In 46 children in median age 6.6 years (range from 1.6 to 16) we evaluated at the time of diagnosis, after protocol I and after intensive treatment, height, body mass index (BMI) and IGF-I, IGF-II, IGFBP-3, IGFBP-2 and leptin. RESULTS: Height SDS lowered in successive points of analysis whereas BMI SDS rose after protocol II. IGF-I SDS was low and similar at each point, IGF-II SDS and IGFBP-3 SDS values augmented progressively and IGFBP-2 SDS was significantly elevated before treatment and lowered (but not normalized) during the therapy. Leptin SDS was elevated, especially after protocol I. CONCLUSION: Leukaemia and its treatment affect directly growth factors, its binding proteins and leptin production leading to growth retardation and overweight.
Authors:
M Krawczuk-Rybak; K Muszyńska-Rosłan; A Kitszel; M Sawicka-Zukowska; S Wołczyński
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Roczniki Akademii Medycznej w Białymstoku (1995)     Volume:  50     ISSN:  -     ISO Abbreviation:  Rocz. Akad. Med. Bialymst.     Publication Date:  2005  
Date Detail:
Created Date:  2005-12-19     Completed Date:  2006-01-31     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9515551     Medline TA:  Rocz Akad Med Bialymst     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  208-11     Citation Subset:  IM    
Affiliation:
Department of Pediatric Oncology, Medical University of Białystok, Poland. rybak@amb.edu.pl
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Antineoplastic Agents / therapeutic use
Body Constitution*
Body Height
Child
Child, Preschool
Female
Growth Disorders / blood,  drug therapy*
Humans
Infant
Insulin-Like Growth Factor Binding Protein 2 / blood*
Insulin-Like Growth Factor Binding Protein 3 / blood*
Insulin-Like Growth Factor I / metabolism*
Insulin-Like Growth Factor II / metabolism*
Leptin / blood*
Male
Overweight
Precursor Cell Lymphoblastic Leukemia-Lymphoma / blood*,  drug therapy
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Insulin-Like Growth Factor Binding Protein 2; 0/Insulin-Like Growth Factor Binding Protein 3; 0/Leptin; 67763-96-6/Insulin-Like Growth Factor I; 67763-97-7/Insulin-Like Growth Factor II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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