Document Detail

Relationship between the initial dimensions of bronchial ring and its contraction after acetylcholine (author's transl)
MedLine Citation:
PMID:  1016794     Owner:  NLM     Status:  MEDLINE    
Contractions produced by comulative doses of acetylcholine were studied in isolated canine bronchical rings from 2 to 10 mm internal diameter. The maximal active tension achieved was directly related to the initial caliber of the ring and to the amount of smooth muscle. The maximal decrease in caliber was relatively greater (--39%) in the smaller than in the larger bronchi (--17%). However the corresponding increase in airway resistance may be predicted to be more important in the larger resistive bronchi.
S Delpierre; P Gayrard
Publication Detail:
Type:  English Abstract; In Vitro; Journal Article    
Journal Detail:
Title:  Bulletin européen de physiopathologie respiratoire     Volume:  12     ISSN:  0395-3890     ISO Abbreviation:  Bull Eur Physiopathol Respir     Publication Date:    1976 Jul-Aug
Date Detail:
Created Date:  1977-04-25     Completed Date:  1977-04-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7605263     Medline TA:  Bull Eur Physiopathol Respir     Country:  FRANCE    
Other Details:
Languages:  fre     Pagination:  555-63     Citation Subset:  IM    
Vernacular Title:
Contraction par l'acétylcholine d'anneaux bronchiques isolés : influence du calibre initial
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MeSH Terms
Acetylcholine / pharmacology*
Airway Resistance
Bronchi / anatomy & histology,  drug effects*,  physiology
Dose-Response Relationship, Drug
Muscle Contraction / drug effects
Muscle, Smooth / anatomy & histology,  drug effects*
Reg. No./Substance:

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