Document Detail

Relationship between infant feeding and infectious illness: a prospective study of infants during the first year of life.
MedLine Citation:
PMID:  2314958     Owner:  NLM     Status:  MEDLINE    
Prior studies investigating the relationship between infant feeding and infectious illnesses in developed countries have provided conflicting data about whether breast-feeding protects against common infectious illnesses early in life. These conflicts may in part be due to the failure to consider the following methodologic issues: (1) collecting data prospectively at frequent intervals for active surveillance of the detection of infections and of feeding practices, (2) specifying what is meant by infectious illnesses and breast-feeding, (3) controlling for confounding variables such as social class or presence of siblings in the household, and (4) applying appropriate analytical strategies to a population in which both feeding and exposure to illness change over time. A total of 500 infants born consecutively in a university-affiliated community hospital in Copenhagen, Denmark, were studied prospectively for the first 12 months of life by means of a detailed, monthly, mailed questionnaire that focused on feeding practices and illnesses (overall response rate, 73%). The percentage of infants who were completely or mostly breast-fed decreased from 88% at 1 month to 20% at 12 months of age. After adjustment for major covariates, no statistically significant relationship was found between the type of infant feeding and the incidence of four categories of infectious illnesses: gastroenteritis, upper respiratory illness, otitis media, and lower respiratory illness. The adjusted incidence density ratio for gastroenteritis was 1.067 (95% confidence interval = 0.982, 1.226) and for upper respiratory illnesses 0.984 (95% confidence interval = 0.883, 1.096).(ABSTRACT TRUNCATED AT 250 WORDS)
D H Rubin; J M Leventhal; P A Krasilnikoff; H S Kuo; J F Jekel; B Weile; A Levee; M Kurzon; A Berget
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatrics     Volume:  85     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-04-19     Completed Date:  1990-04-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  464-71     Citation Subset:  AIM; IM    
Division of Pediatric, Albert Einstein College of Medicine-Montefiore Medical Center, Bronx, New York.
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MeSH Terms
Breast Feeding*
Denmark / epidemiology
Follow-Up Studies
Gastroenteritis / epidemiology*
Infant Food*
Infant, Newborn
Otitis Media / epidemiology
Prospective Studies
Respiratory Tract Infections / epidemiology*
Socioeconomic Factors
Grant Support
MCJ-360554//PHS HHS
Comment In:
Pediatrics. 1990 Nov;86(5):806-7   [PMID:  2235242 ]
Pediatrics. 1991 Nov;88(5):1079-80   [PMID:  1945625 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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