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Relationship between individual cardiovascular risk factors and localization of coronary atherosclerotic lesions.
MedLine Citation:
PMID:  20739064     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: The localization of coronary atherosclerotic lesions in patients with coronary artery disease is important. We investigated the relationship between individual cardiovascular risk factors and lesion localization in the coronary arteries.
METHODS: We studied 200 consecutive patients with suspected or known coronary artery disease who were referred for coronary angiography because of chest pain. We assessed the following cardiovascular risk factors: male gender, hypercholesterolemia, smoking, arterial hypertension, positive family history, and diabetes. We evaluated atherosclerotic lesions creating a stenosis ≥ 50% in the 3 coronary arteries and lesions creating a stenosis ≥ 30% in the left main stem.
RESULTS: Of the 200 study patients, 155 (78%) showed at least 1 coronary artery lesion with a luminal stenosis ≥ 50%. With an increasing number of risk factors, there was a significant progressive increase of diseased arteries (P < .001). There was a differential association between individual risk factors and lesions in the 3 coronary arteries. Male gender, hypercholesterolemia, and diabetes were predictors of lesions in the left anterior descending artery (odds ratios 2.365, 2.510, and 1.998, respectively). Predictors of left circumflex artery lesions were male gender, smoking, and diabetes (odds ratios 2.581, 1.913, and 2.280, respectively), whereas the only independent predictor of right coronary artery lesions was male gender (odds ratio 2.995). Diabetes was also significantly associated with lesions in the diagonal branches of the left anterior descending artery and the marginal branches of the left circumflex artery.
CONCLUSION: Individual cardiovascular risk factors are associated with the localization of atherosclerotic lesions in the coronary circulation.
Authors:
Myrto Trianti; Theodoros Xanthos; Nicoletta Iacovidou; Nikolaos Dagres; John P Lekakis; Fani Kyriakou; Dimitrios T Kremastinos
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Publication Detail:
Type:  Journal Article     Date:  2010-08-23
Journal Detail:
Title:  Heart & lung : the journal of critical care     Volume:  40     ISSN:  1527-3288     ISO Abbreviation:  Heart Lung     Publication Date:    2011 May-Jun
Date Detail:
Created Date:  2011-05-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0330057     Medline TA:  Heart Lung     Country:  United States    
Other Details:
Languages:  eng     Pagination:  201-7     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Department of Pneumology, 401 General Military Hospital, Athens, Greece.
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