Document Detail

Relationship between hypertriglyceridemia and uric acid production in primary gout.
MedLine Citation:
PMID:  2739579     Owner:  NLM     Status:  MEDLINE    
The relationship between uric acid metabolism and lipid levels was analyzed in 148 male subjects with primary gout. The subjects were divided into three groups according to their alcohol consumption: heavy drinkers, moderate drinkers, and nondrinkers or mild drinkers. There was no correlation between urinary uric acid excretion and serum triglyceride (TG) levels in the heavy group, but a marginally significant correlation was shown in the moderate group (P less than .05), and a significant correlation was observed in the nondrinker or mild group (P less than .001). This relationship in the nondrinker or mild group was also found to be significant after adjustment for BMI and age by multiple regression analysis. Serum lipoproteins were analyzed by sequential preparative ultracentrifugation in 21 patients with primary gout who neither drank alcohol nor were obese; VLDL-TG level, but not the VLDL cholesterol level, was found to be significantly correlated with 24-hour urinary uric acid excretion. These results indicate that there is a close correlation between the degree of uric acid production, as judged by 24-hour urinary uric acid excretion, and lipoprotein TG metabolism when the influence of alcohol intake is excluded.
K Matsubara; Y Matsuzawa; S Jiao; T Takama; M Kubo; S Tarui
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  38     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-08-10     Completed Date:  1989-08-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  698-701     Citation Subset:  IM    
Second Department of Internal Medicine, Osaka University Medical School, Japan.
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MeSH Terms
Alcohol Drinking
Cholesterol / blood
Cholesterol, HDL / blood
Gout / blood*,  complications,  urine
Hypertriglyceridemia / blood*,  complications
Reference Values
Triglycerides / blood
Uric Acid / blood*,  urine
Reg. No./Substance:
0/Cholesterol, HDL; 0/Triglycerides; 57-88-5/Cholesterol; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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