Document Detail


Relationship between human cytomegalovirus glycoprotein B genotype and serum alanine aminotransferase elevation in infants.
MedLine Citation:
PMID:  15297739     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The glycoprotein B (gB) region of the human cytomegalovirus (HCMV) is a major envelope glycoprotein that is a principal target of neutralizing antibodies and is known to stimulate the immune response of cytotoxic T lymphocytes. HCMV is currently classified into four genotypes on the basis of the nucleotide sequence of the gB region. The presence of HCMV in patients under 3 years of age was determined by subjecting urine samples taken from the patients to polymerase chain reaction (PCR) analysis. Analysis by direct sequencing of the gB region was carried out in 90 cases. These cases were grouped into the gB genotype 1 and gB genotype 3. Of 28 cases with a peak serum alanine aminotransferase (ALT) level(> or =100 IU/l), the duration of observed serum ALT elevation in the gB genotype 1 patients (166.7+/-126.7 days [mean+/-S.D.] [19 cases]) was significantly longer than that in the gB genotype 3 patients (39.7+/-31.7 days [9 cases]) (p<0.01). In the 54 cases with a serum ALT level(> or =50 IU/l), similar tendency was seen (p<0.05). These findings suggest that when serum ALT elevation is confirmed in young children infected with HCMV, analysis of the gB region is helpful for prediction of the duration of serum ALT elevation in the early stage of infection.
Authors:
Koji Terabe; Kohachiro Sugiyama; Kenji Goto; Fumihiko Mizutani; Yoshiro Wada; Takao Yokoyama; Yoshihiro Ando
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  203     ISSN:  0040-8727     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-08-06     Completed Date:  2005-01-13     Revised Date:  2008-08-26    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  339-44     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Nagoya City University Medical School, Kawasumi-cho, Mizuho-ku, Japan. kids86@gctv.ne.jp
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MeSH Terms
Descriptor/Qualifier:
Alanine Transaminase / blood*
Base Sequence
Child, Preschool
Cytomegalovirus / genetics*
DNA, Viral / analysis,  isolation & purification
Electrophoresis, Agar Gel
Female
Genotype*
Humans
Infant
Male
Polymerase Chain Reaction
Retrospective Studies
Simplexvirus / genetics*
Urine / virology
Viral Envelope Proteins / chemistry,  genetics*
Chemical
Reg. No./Substance:
0/DNA, Viral; 0/Viral Envelope Proteins; 0/glycoprotein B, Simplexvirus; EC 2.6.1.2/Alanine Transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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