Document Detail

Relationship between histopathologic gastritis and mucosal microvascularity: observations with magnifying endoscopy.
MedLine Citation:
PMID:  12838224     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The purpose of this study was to determine the usefulness of magnifying endoscopy for the diagnosis of Helicobacter pylori-induced histopathologic gastritis. METHODS: A total of 92 patients scheduled to undergo routine endoscopic examination were enrolled. After routine endoscopic examination, 3 sites in the stomach were studied by magnified observation. Visualized collecting venulae were classified into the following 3 patterns: regular, irregular, and obscured. The sites observed by magnifying endoscopy were assessed histopathologically with an Updated Sydney System; 4 morphologic parameters (activity, inflammation, atrophy, metaplasia) were assessed and graded from 0 to 3. RESULTS: The regular pattern cases were negative for H pylori infection at all sites observed by magnifying endoscopy (antrum greater curve, 0/11; body greater curve, 0/24; body lesser curve, 0/23). The scores for all 4 morphologic parameters were significantly lower in the regular pattern group than the irregular and obscured groups (p < 0.01). The value of the atrophy parameter in the irregular group was significantly higher than that in the obscured group (p < 0.05 for a single test of hypothesis; correction for multiple testing of data removed significance). CONCLUSION: Visibility of collecting venulae in the gastric mucosa is influenced by H pylori-induced histopathologic gastritis. Magnifying endoscopy is useful for the diagnosis of histopathologic gastritis.
Souichi Nakagawa; Mototsugu Kato; Yuichi Shimizu; Manabu Nakagawa; Junji Yamamoto; Perez Aldana Luis; Junichi Kodaira; Mitsuru Kawarasaki; Hirosh Takeda; Toshiro Sugiyama; Masahiro Asaka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gastrointestinal endoscopy     Volume:  58     ISSN:  0016-5107     ISO Abbreviation:  Gastrointest. Endosc.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-02     Completed Date:  2003-11-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0010505     Medline TA:  Gastrointest Endosc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  71-5     Citation Subset:  IM    
Department of Gastroenterology and Division of Endoscopy, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
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MeSH Terms
Cohort Studies
Follow-Up Studies
Gastric Mucosa / blood supply*,  pathology
Gastritis / microbiology,  pathology*
Gastroscopy / methods*
Helicobacter Infections / diagnosis,  pathology*
Helicobacter pylori / isolation & purification*
Prospective Studies
Radiographic Magnification
Sensitivity and Specificity
Severity of Illness Index
Comment In:
Gastrointest Endosc. 2004 Apr;59(4):596-7; author reply 597   [PMID:  15044912 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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