Document Detail

Relationship between high density lipoprotein antioxidant activity and carotid arterial intima-media thickness in patients with essential hypertension.
MedLine Citation:
PMID:  20144068     Owner:  NLM     Status:  MEDLINE    
The objective of this study was to evaluate high-density lipoprotein (HDL) antioxidative activity and its possible influencing factors in patients with essential hypertension and to investigate the correlations between HDL antioxidative activity and the carotid arterial intima-media thickness (CIMT). Thirty-three patients with essential hypertension and 32 healthy people as control were included. High- and low-density lipoprotein in plasma were isolated by one-step density gradient ultracentrifugation, and induced oxidation with external Cu(2+). Antioxidant activity of HDL, lag time, and lipid peroxidation degree were determined by spectrophotometric and thiobarbituric acid reactive substances (TBARS) methods. Paraoxonase 1 (PON1) activity in serum was measured with continuous monitoring using phenylacetate as a substrate. The CIMT was measured with a high-resolution ultrasound Doppler system. In patients with essential hypertension, the inhibitory effect of HDL on low-density lipoprotein (LDL) oxidation and the PON1 activity were reduced (72.29 +/- 2.03)% vs. (80.91 +/- 2.06)%, and (112.21 +/- 8.64)u/ml vs. (146.43 +/- 8.79)u/ml (all P < 0.05). The lag time of oxidation and the lipid peroxidation between the hypertensive group and the control group did not show a statistically significant difference. Multiple stepwise regression analysis revealed that HDL antioxidative activity might be affected by PON1 activity (P = 0.004), diastolic pressure (P = 0.004), sex (P = 0.006), and that CIMT might be affected by HDL antioxidative activity (P = 0.030), systolic pressure (P = 0.026), and total cholesterol level (P = 0.033). The HDL antioxidative activity is reduced in patients with essential hypertension and significantly affected by sex. The CIMT was negatively correlated with HDL antioxidative activity, which suggests that decreased HDL antioxidative activity may be one of the important determinants for the development of atherosclerosis in patients with essential hypertension.
Xiaoping Chen; Yuelei Wu; Liyun Liu; Yanling Su; Yong Peng; Lingyun Jiang; Xiaojing Liu; Dejia Huang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  32     ISSN:  1525-6006     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-10     Completed Date:  2010-05-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  13-20     Citation Subset:  IM    
Department of Cardiology, West China Hospital of Sichuan University, Chengdu, China.
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MeSH Terms
Antioxidants / metabolism*
Aryldialkylphosphatase / blood
Carotid Arteries / pathology*,  ultrasonography
Case-Control Studies
Hypertension / blood*,  pathology*
Linear Models
Lipid Peroxidation
Lipoproteins, HDL / blood*
Lipoproteins, LDL / blood
Middle Aged
Tunica Intima / pathology
Tunica Media / pathology
Reg. No./Substance:
0/Antioxidants; 0/Lipoproteins, HDL; 0/Lipoproteins, LDL; EC; EC protein, human

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