Document Detail

Relationship between high aortic pulse pressure and extension of coronary atherosclerosis in males.
MedLine Citation:
PMID:  20945964     Owner:  NLM     Status:  MEDLINE    
A high pulse pressure (PP) is a marker of increased artery stiffness and represents a well-established independent predictor for cardiovascular morbidity and mortality. The objective of the research was to determine whether invasively measured central aortic PP was related to the presence and severity of coronary artery disease. In total 1075 consecutive stable male patients undergoing diagnostic coronary angiography with a preserved left ventricular function were included. Diseased coronary vessel (DCV) was defined by the presence of >50 % stenosis. Men were divided into 3 groups according to the increased value of PP. The average PP in the tertiles was 47.8+/-7.1 vs. 67.0+/-4.9 vs. 91.3+/-12.8 mm Hg (p<0.01). The significant differences of DCV was found among tertiles (1.51+/-1.11 vs 1.80+/-1.04 vs. 1.99+/-0.98 DCV, p<0.01). Aortic PP together with age and hyperlipoproteinemia were found as factors with an independent relationship to DCV according to multivariate linear regression. In conclusions the increased value of aortic PP in the male population is independently connected with more severe atherosclerosis evaluated by the significant number of DCV.
J Pařenica; P Kala; J Jarkovský; M Poloczek; O Boček; P Jeřábek; P Neugebauer; M Vytiska; I Pařenicová; D Tomčíková; M Pávková Goldbergová; J Spinar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-15
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  60     ISSN:  1802-9973     ISO Abbreviation:  Physiol Res     Publication Date:  2011  
Date Detail:
Created Date:  2011-04-07     Completed Date:  2011-08-09     Revised Date:  2011-10-21    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  47-53     Citation Subset:  IM    
Cardiology Department, Faculty Hospital Brno, Brno, Czech Republic.
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MeSH Terms
Aorta / physiology*
Blood Pressure / physiology
Coronary Angiography
Coronary Artery Disease / physiopathology*
Multivariate Analysis
Pulsatile Flow / physiology
Vascular Resistance / physiology
Ventricular Function, Left / physiology

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