| Relationship between high aortic pulse pressure and extension of coronary atherosclerosis in males. | |
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MedLine Citation:
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PMID: 20945964 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A high pulse pressure (PP) is a marker of increased artery stiffness and represents a well-established independent predictor for cardiovascular morbidity and mortality. The objective of the research was to determine whether invasively measured central aortic PP was related to the presence and severity of coronary artery disease. In total 1075 consecutive stable male patients undergoing diagnostic coronary angiography with a preserved left ventricular function were included. Diseased coronary vessel (DCV) was defined by the presence of >50 % stenosis. Men were divided into 3 groups according to the increased value of PP. The average PP in the tertiles was 47.8+/-7.1 vs. 67.0+/-4.9 vs. 91.3+/-12.8 mm Hg (p<0.01). The significant differences of DCV was found among tertiles (1.51+/-1.11 vs 1.80+/-1.04 vs. 1.99+/-0.98 DCV, p<0.01). Aortic PP together with age and hyperlipoproteinemia were found as factors with an independent relationship to DCV according to multivariate linear regression. In conclusions the increased value of aortic PP in the male population is independently connected with more severe atherosclerosis evaluated by the significant number of DCV. |
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Authors:
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J Pařenica; P Kala; J Jarkovský; M Poloczek; O Boček; P Jeřábek; P Neugebauer; M Vytiska; I Pařenicová; D Tomčíková; M Pávková Goldbergová; J Spinar |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-15 |
Journal Detail:
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Title: Physiological research / Academia Scientiarum Bohemoslovaca Volume: 60 ISSN: 1802-9973 ISO Abbreviation: Physiol Res Publication Date: 2011 |
Date Detail:
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Created Date: 2011-04-07 Completed Date: 2011-08-09 Revised Date: 2011-10-21 |
Medline Journal Info:
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Nlm Unique ID: 9112413 Medline TA: Physiol Res Country: Czech Republic |
Other Details:
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Languages: eng Pagination: 47-53 Citation Subset: IM |
Affiliation:
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Cardiology Department, Faculty Hospital Brno, Brno, Czech Republic. jiri.parenica@atlas.cz |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aorta
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physiology* Blood Pressure / physiology Coronary Angiography Coronary Artery Disease / physiopathology* Humans Male Multivariate Analysis Pulsatile Flow / physiology Vascular Resistance / physiology Ventricular Function, Left / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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