Document Detail

Relationship between hemoglobin and CD40 ligand in prediabetes.
MedLine Citation:
PMID:  20003829     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Hemoglobin (Hb) regulates the endothelial function by modulating the bio-availability of NO at the tissue level. A significant direct relationship is present between the Hb levels and endothelial functions in patients with Type 2 diabetes. Testing whether this association also exists in subjects with prediabetes is important because prediabetes is associated with an increased risk of cardiovascular disease and mortality. Therefore, we investigated the association of Hb both with the classical cardiac risk factors and the markers for endothelial dysfunction and inflammation, in subjects with impaired glucose tolerance (IGT). METHODS: We enrolled 69 normotensive, and cardiovascular events free subjects with IGT (M=40, age=45.50+/-6.8 yr). Plasma insulin, hsCRP, soluble CD40L, vonWillebrand factor, p-selectin levels were measured. The parameters given according to the higher and lower median Hb values of the subjects were compared. RESULTS: Subjects with the higher Hb levels exhibited lower HDL-C (46.68+/-10.8 mg/dl vs 51.5+/-8.9 mg/dl; P=0.04) and higher systolic (122.57+/-6.2 mmHg vs 116.17+/-7.4 mmHg; p < 0.001) and diastolic (79.14+/-3.73 mmHg vs 75.58+/-6.1 mmHg; P=0.005) blood pressures and sCD40L (7.9+/-3.8 ng/ml vs 6.07+/-2.1 ng/ml; P=0.02) levels. Hb levels were correlated to the HDL cholesterol, sCD40L, systolic and diastolic blood pressures and waist circumference (r=-0.28, P=0.02; r=0.29, P=0.02; r=0.53, P < 0.001; r=0.41, P=0.001; r=0.42, P < 0.001 respectively). According to the multiple logistic regression analysis, Hb was the determinant of sCD40L levels (beta=0.437, P < 0.001). CONCLUSION: These results indicate that there may be a link with higher Hb values and cardiovascular risk factors in patients with IGT. Further investigation is warranted to understand the clinical implications of these findings in subjects with prediabetes.
Mustafa Kutlu; Alper Sonmez; Halil Genc; Gokhan Erdem; Serkan Tapan; Gurkan Celebi; Cem Haymana; Abdullah Taslipinar; Gokhan Uckaya; Mehmet Kemal Erbil
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Publication Detail:
Type:  Journal Article     Date:  2009-12-01
Journal Detail:
Title:  Clinical and investigative medicine. M?decine clinique et experimentale     Volume:  32     ISSN:  1488-2353     ISO Abbreviation:  Clin Invest Med     Publication Date:  2009  
Date Detail:
Created Date:  2009-12-16     Completed Date:  2010-03-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7804071     Medline TA:  Clin Invest Med     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  E244     Citation Subset:  IM    
Department of Endocrinology, Gulhane Medical School, Etlik, 06018 Ankara, Turkey.
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MeSH Terms
C-Reactive Protein / metabolism
CD40 Ligand / blood*
Glucose Tolerance Test
Hemoglobins / metabolism*
Insulin / blood
Middle Aged
Multivariate Analysis
Prediabetic State / blood*,  physiopathology
Reg. No./Substance:
0/Hemoglobins; 11061-68-0/Insulin; 147205-72-9/CD40 Ligand; 9007-41-4/C-Reactive Protein

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