Document Detail


Relationship between the hemodynamic changes on multi-Td pulsed arterial spin labeling images and the degrees of cerebral artery stenosis.
MedLine Citation:
PMID:  25171819     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To explore the relationship between the hemodynamic changes on multi-Td(delay time) pulsed arterial spin labeling(PASL) images and the degrees of cerebral artery stenosis, and to evaluate the value of multi-Td PASL in detecting the signal changes in cerebral arteries with stenosis.
PATIENTS AND METHODS: 29 patients with less than 50% stenosis (mild stenosis group) and 22 patients with 50%-69% stenosis (moderate stenosis group) in M1 segment of unilateral middle cerebral artery (MCA) were included in this study. The degrees of MCA stenosis were measured using time of flight MR angiography (TOF MRA). Multi-Td PASL imaging was performed to detect the signal changes in bilateral MCA. We selected and hand-drew bilateral symmetric branches of MCA as regions of interest (ROIs) on eight-Td PASL images. The intensities of ROIs were measured and the time-signal intensity curves were acquired by post-processing on a MR workstation. SPSS19.0 statistical software was used for statistics. The differences in the peak intensities and the times to peak intensities between the normal and narrowed sides of the mild and moderate stenosis groups were respectively examined by paired-samples t test. The differences in the changes of peak intensities and times to peak intensity of the two sides between the mild and moderate stenosis groups were examined by independent samples t test. A p value less than 0.05 was considered statistically significant.
RESULT: There were significant difference in the peak intensities (t=-2.720, P=0.011<0.05) and no significant difference in the times to peak intensities (t=-1.279, P=0.212>0.05) between the normal and narrowed sides of the mild stenosis group. There were both significant differences in the peak intensities (t=-6.076, P=0.000<0.05) and times to peak intensities (t=7.232, P=0.000<0.05) between the normal side and narrowed side of the moderate stenosis group. There were both significant differences in the changes of peak intensities (t=-2.11, p=0.040<0.05) and times to peak intensity (t=-4.23, p=0.000<0.05) between the mild and moderate stenosis groups.
CONCLUSION: The hemodynamic changes on multi-Td PASL images were different with the degrees of cerebral artery stenosis. Moderate stenosis means greater hemodynamic changes in the arteries than mild stenosis. Multi-Td PASL imaging is a promising means to evaluate the hemodynamic changes in cerebral arteries with stenosis.
Authors:
Jun Chen; Bin Zhao; Chunqing Bu; Guohua Xie
Related Documents :
20017449 - Pulmonary arterial hypertension--contemporary management strategy.
14529159 - Pathological lesions causing pulmonary hypertension after closure of a ventricular sept...
8287439 - Role of 5-hydroxytryptamine in the progression of monocrotaline induced pulmonary hyper...
16292989 - Sitaxsentan: a novel endothelin-a receptor antagonist for pulmonary arterial hypertension.
8342199 - The effects of hypertension on cerebral atherosclerosis in the cynomolgus monkey.
1153689 - Pulmonary veno-occlusive disease.
14018909 - Infarction of the human liver.
24858329 - Clinical importance of the middle meningeal artery.
9563439 - Nodular amyloidosis of the lung from intravenous drug abuse: an uncommon cause of multi...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-26
Journal Detail:
Title:  Magnetic resonance imaging     Volume:  -     ISSN:  1873-5894     ISO Abbreviation:  Magn Reson Imaging     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8214883     Medline TA:  Magn Reson Imaging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier Inc.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Use and limitations of Cardiac Magnetic Resonance derived measures of aortic stiffness in patients a...
Next Document:  4-D MR Phase and Magnitude Segmentations with GPU Parallel Computing.