| Relationship between head circumference and height in normal adults and in the nevoid basal cell carcinoma syndrome and neurofibromatosis type I. | |
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MedLine Citation:
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PMID: 1910262 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Occipitofrontal circumference (OFC) was strongly correlated with height in 72 normal Caucasian men (r = 0.28, P = 0.018) and 78 women (r = 0.53, P less than 0.0001). OFC:height ratios were approximately normally distributed in each sex with a mean of 0.326 (standard deviation [sd] = 0.0139) in males and 0.335 (sd = 0.0177) in females. Relative macrocephaly (an OFC greater than the 95th centile for height) was seen in seven of nine probands with the nevoid basal cell carcinoma syndrome (NBCC), eight of 32 non-probands with NBCC, three of four neurofibromatosis type 1 (NF1) probands, and six of nine non-probands with NF1. Thirty-one percent of the non-proband NBCC cases had OFC less than the 50th centile for height, while none of the NF1 cases had this finding. Head size appears to be related to proband status in NBCC, while the evidence suggests that NF1 is a true macrocephaly syndrome. Objective detection of relative abnormalities in head size may aid in syndrome delineation and diagnosis. |
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Authors:
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S J Bale; C I Amos; D M Parry; A E Bale |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of medical genetics Volume: 40 ISSN: 0148-7299 ISO Abbreviation: Am. J. Med. Genet. Publication Date: 1991 Aug |
Date Detail:
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Created Date: 1991-10-24 Completed Date: 1991-10-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7708900 Medline TA: Am J Med Genet Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 206-10 Citation Subset: IM |
Affiliation:
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Environmental Epidemiology Branch, National Cancer Institute, Bethesda, Maryland 20892. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Basal Cell Nevus Syndrome / pathology* Body Height* Cephalometry* European Continental Ancestry Group Female Humans Male Middle Aged Neurofibromatosis 1 / pathology* Reference Values |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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