Document Detail


Relationship between glycosylated hemoglobin and arterial elasticity.
MedLine Citation:
PMID:  16849879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Arterial elasticity is decreased in diabetes, but it is unclear whether there is a relationship between glycosylated hemoglobin (HbA1c) and arterial elasticity. To evaluate this question, 111 subjects with diabetes mellitus had HbA1c and arterial elasticity determined in an academic outpatient setting. Three measurements of arterial elasticity indices were obtained supine using the HDI/PulseWave CR-2000 Research CardioVascular Profiling System (Hypertension Diagnostics Inc., Eagan, MN). The study population was 49% black and 51% women. Population characteristics included age, 49.2 years; duration of diabetes, 12.1 years; HbA1c, 8.9%; large artery elasticity, 11.8 mL/mm Hg x 10; and small artery elasticity, 4.7 mL/mm Hg x 100. Age correlated with diminished large artery elasticity. Women had a lower large artery elasticity than men (10.6 vs. 13.3 mL/mm Hg x 10; p = 0.0002). Decreasing small artery elasticity was associated with increasing age (p = 0.0001), HbA1c (p = 0.0184), and African-American ethnicity (p = 0.0306). Women had less small artery elasticity than men (3.8 vs. 5.8 mL/mm Hg x 100; p = 0.0001). Black diabetic patients had a reduced arterial elasticity compared with whites. Increasing HbA1c is associated with decreasing small artery elasticity, but not large artery elasticity. In diabetic patients, small artery elasticity is reduced to a greater extent in women than men and in blacks than whites.
Authors:
L Michael Prisant; Puja Mehta; Vishal Arora; Mindy Gentry; Jennifer L Waller
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Preventive cardiology     Volume:  9     ISSN:  1520-037X     ISO Abbreviation:  Prev Cardiol     Publication Date:  2006  
Date Detail:
Created Date:  2006-07-19     Completed Date:  2006-10-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9813731     Medline TA:  Prev Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  160-5     Citation Subset:  IM    
Affiliation:
Medical College of Georgia, Augusta, GA 30912-3104, USA. mprisant@mail.mcg.edu
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Arteries / physiopathology*
Cardiovascular Diseases / prevention & control
Diabetes Mellitus / blood,  physiopathology*
Elasticity
Ethnic Groups
Female
Hemoglobin A, Glycosylated / analysis,  metabolism*
Humans
Linear Models
Male
Middle Aged
Sex Factors
Chemical
Reg. No./Substance:
0/Hemoglobin A, Glycosylated

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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