| Relationship between glutathione and DL alpha-lipoic acid against cadmium-induced hepatotoxicity. | |
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MedLine Citation:
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PMID: 8806036 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cadmium, a divalent metal toxicant, preferentially localizes in hepatocytes and causes liver injury. DL alpha-lipoic acid is a dithiol which is effective in rendering protection against cadmium-associated liver damage, by virtue of its two sulfhydryl moieties. Lipoate was administered to cadmium-exposed rats which were either prior administered with buthionine sulfoximine to deplete liver glutathione or not. During lipoate treatment, significant protection was rendered against cadmium toxicity even under glutathione-depleted experimental condition. This highlights the antioxidant property of lipoic acid and its efficacy in mitigating cadmium-associated liver assault even in the absence of glutathione synthesis. |
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Authors:
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R Sumathi; G Baskaran; P Varalakshmi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Japanese journal of medical science & biology Volume: 49 ISSN: 0021-5112 ISO Abbreviation: Jpn. J. Med. Sci. Biol. Publication Date: 1996 Apr |
Date Detail:
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Created Date: 1996-11-22 Completed Date: 1996-11-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0243706 Medline TA: Jpn J Med Sci Biol Country: JAPAN |
Other Details:
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Languages: eng Pagination: 39-48 Citation Subset: IM |
Affiliation:
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Department of Medical Biochemistry, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Buthionine Sulfoximine / pharmacology Cadmium / toxicity* Glutathione / physiology* Lipid Peroxidation / drug effects Liver / drug effects* Male Rats Rats, Wistar Thioctic Acid / physiology* |
| Chemical | |
Reg. No./Substance:
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5072-26-4/Buthionine Sulfoximine; 62-46-4/Thioctic Acid; 70-18-8/Glutathione; 7440-43-9/Cadmium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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