Document Detail


Relationship between glutathione and DL alpha-lipoic acid against cadmium-induced hepatotoxicity.
MedLine Citation:
PMID:  8806036     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cadmium, a divalent metal toxicant, preferentially localizes in hepatocytes and causes liver injury. DL alpha-lipoic acid is a dithiol which is effective in rendering protection against cadmium-associated liver damage, by virtue of its two sulfhydryl moieties. Lipoate was administered to cadmium-exposed rats which were either prior administered with buthionine sulfoximine to deplete liver glutathione or not. During lipoate treatment, significant protection was rendered against cadmium toxicity even under glutathione-depleted experimental condition. This highlights the antioxidant property of lipoic acid and its efficacy in mitigating cadmium-associated liver assault even in the absence of glutathione synthesis.
Authors:
R Sumathi; G Baskaran; P Varalakshmi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Japanese journal of medical science & biology     Volume:  49     ISSN:  0021-5112     ISO Abbreviation:  Jpn. J. Med. Sci. Biol.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-11-22     Completed Date:  1996-11-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0243706     Medline TA:  Jpn J Med Sci Biol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  39-48     Citation Subset:  IM    
Affiliation:
Department of Medical Biochemistry, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, India.
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MeSH Terms
Descriptor/Qualifier:
Animals
Buthionine Sulfoximine / pharmacology
Cadmium / toxicity*
Glutathione / physiology*
Lipid Peroxidation / drug effects
Liver / drug effects*
Male
Rats
Rats, Wistar
Thioctic Acid / physiology*
Chemical
Reg. No./Substance:
5072-26-4/Buthionine Sulfoximine; 62-46-4/Thioctic Acid; 70-18-8/Glutathione; 7440-43-9/Cadmium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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