Document Detail

Relationship between a genetic predisposition to hypertension, blood pressure levels and pain sensitivity.
MedLine Citation:
PMID:  10488683     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: The aim of this study was to determine whether the degree of blood pressure elevation and/or a genetic predisposition to hypertension have a major role in determining a reduced pain perception in hypertensives. The reasons underlying the relationship between blood pressure elevation and pain perception mechanisms are not completely understood. METHODS: One hundred and four untreated hypertensive patients (65 subjects with and 39 without a positive parental history of hypertension) together with a control group of 42 subjects (20 normotensive offspring of normotensive parents, and 22 normotensive offspring of hypertensive parents) were submitted to standard blood pressure evaluation, 24-h blood pressure monitoring and dental pain perception evaluation. RESULTS: Both pain threshold and tolerance were found to be higher in hypertensive than normotensive subjects (P < 0.0001 and P < 0.015, respectively). Positive significant correlations were found between both 24-h systolic and diastolic pressure and the pain perception variables. When a 2 x 2 ANOVA test was performed, factoring for the effects of both blood pressure status and family history of hypertension on pain sensitivity, a significant effect was revealed only for blood pressure status. Moreover, after controlling for blood pressure by a covariate analysis, no significant difference was found between the subjects with or without hypertensive parents as regards pain perception variables. CONCLUSIONS: Pain sensitivity is correlated to blood pressure levels whereas the parental history of hypertension per se does not affect the pain perception pattern. Thus, the degree of blood pressure elevation, more than a genetic predisposition to hypertension may influence the mechanisms leading to hypalgesia in hypertension.
L Guasti; G Gaudio; D Zanotta; P Grimoldi; M R Petrozzino; F Tanzi; A Bertolini; A M Grandi; A Venco
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pain     Volume:  82     ISSN:  0304-3959     ISO Abbreviation:  Pain     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-10-19     Completed Date:  1999-10-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7508686     Medline TA:  Pain     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  311-7     Citation Subset:  IM    
Department of Clinical and Biological Sciences, Faculty of Medicine, University of Insubria, Varese, Italy.
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MeSH Terms
Analysis of Variance
Blood Pressure / physiology*
Case-Control Studies
Dental Pulp / physiopathology
Electric Stimulation
Family Health
Genetic Predisposition to Disease
Hypertension / genetics*
Linear Models
Medical History Taking
Middle Aged
Pain Threshold / physiology*
Toothache / physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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