| Relationship between gastroesophageal reflux disease and myocardial ischemia. Effect of reflux on temporary activity of autonomic nervous system. | |
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MedLine Citation:
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PMID: 15631321 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Assessment of the gastroesophageal reflux disease (GERD) influence on myocardial ischemia and autonomic nervous system (ANS) activity. MATERIAL AND METHODS: In 50 patients with angiographically confirmed ischemic heart disease (IHD) in I-III CCS class, simultaneous 24-hour ECG and esophageal pH-metry monitoring was performed. We assessed: (1) GERD occurrence in patients with IHD, (2) influence of pathological reflux (PR) on myocardial ischemia--number and total duration of ST depression episodes in GERD and non-GERD patients, (3) temporary activity of ANS was determined according to the dynamics of spectral HRV (Heart Rate Variability) analysis components (LF, HF, VLF, LF/HF). RESULTS: 23 patients (46%) fullfilled the GERD criteria. Patients with GERD had significantly higher number of ST depression episodes (4.13 vs 2.85, p = 0.013) as well as longer total duration of ischemia (64.73 vs 35.2 min, p = 0.034). Spectral HRV analysis showed the significant decrease of LF/HF ratio (p < 0.035), which indicates the sympathovagal balance shift towards the parasympathetic system caused by PR. CONCLUSIONS: 1. GERD is frequent condition in patients with angiographically confirmed IHD. Coexistence of GERD may predispose to the myocardial ischemia. 2. Gastroesophageal reflux may cause the shift of sympathovagal balance towards its parasympathetic component. This mechanism may induce esophago-cardiac reflex, leading to diminished myocardial perfusion. |
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Authors:
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S Dobrzycki; D Skrodzka; W J Musiał; M Go; J Korecki; K Gugała; P Kralisz; P Prokopczuk; H Bachórzewska-Gajewska; K Kamiński |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Roczniki Akademii Medycznej w Białymstoku (1995) Volume: 49 ISSN: - ISO Abbreviation: Rocz. Akad. Med. Bialymst. Publication Date: 2004 |
Date Detail:
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Created Date: 2005-01-05 Completed Date: 2005-03-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9515551 Medline TA: Rocz Akad Med Bialymst Country: Poland |
Other Details:
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Languages: eng Pagination: 93-7 Citation Subset: IM |
Affiliation:
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Invasive Cardiology Department, Medical University of Białystok, Poland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Autonomic Nervous System / physiopathology* Electrocardiography, Ambulatory Female Gastric Acidity Determination Gastroesophageal Reflux / complications*, metabolism, physiopathology Heart Conduction System / physiopathology* Heart Rate Humans Hydrogen-Ion Concentration Male Middle Aged Myocardial Ischemia / complications*, metabolism, physiopathology* |
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