| Relationship between gamma-aminobutyric acid metabolism and antivitamin B6-induced convulsions. | |
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MedLine Citation:
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PMID: 712435 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The correlation between the gamma-aminobutyric acid (GABA) metabolism and convulsions by some vitamin B6 antagonists, DL-penicillamine (PeA), hydrazine (Hyd), thiosemicarbazide (TSC) were investigated. Glutamic acid decarboxylase (GAD) and gamma-aminobutyric acid transaminase (GABA-T) activities were inhibited during convulsions by three antagonists, and GABA content was not changed by PeA, increased by Hyd and decreased by TSC in mice whole brain. In subcellular fractions of brain, GAD activity was inhibited and GABA content decreased in synaptosomes during convulsions by the above three drugs. Aminooxyacetic acid (AOAA), a potent GABA-elevating agent, showed an anticonvulsant property against convulsions by TSC for several hours after the injection of AOAA, but lost this property 16hr after treatment. During the convulsions by TSC 16hr after the AOAA-pretreatment, the GABA content in synaptosomes was less than that from the group treated with AOAA alone, though its GABA level was higher than the normal level. From the above results, the GABA content and GAD activity in synaptosomes might be deeply associated with convulsions by B6 antagonists. |
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Authors:
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M Abe |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of nutritional science and vitaminology Volume: 24 ISSN: 0301-4800 ISO Abbreviation: J. Nutr. Sci. Vitaminol. Publication Date: 1978 |
Date Detail:
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Created Date: 1979-01-26 Completed Date: 1979-01-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0402640 Medline TA: J Nutr Sci Vitaminol (Tokyo) Country: JAPAN |
Other Details:
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Languages: eng Pagination: 419-27 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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4-Aminobutyrate Transaminase
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metabolism Acetic Acids / pharmacology* Aminooxyacetic Acid / pharmacology* Animals Brain / drug effects, metabolism* Glutamate Decarboxylase / metabolism Hydrazines / pharmacology* Male Mice Penicillamine / pharmacology* Pyridoxine / antagonists & inhibitors* Seizures / chemically induced, metabolism* Semicarbazides / pharmacology* gamma-Aminobutyric Acid / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Acetic Acids; 0/Hydrazines; 0/Semicarbazides; 52-67-5/Penicillamine; 56-12-2/gamma-Aminobutyric Acid; 645-88-5/Aminooxyacetic Acid; 65-23-6/Pyridoxine; EC 2.6.1.19/4-Aminobutyrate Transaminase; EC 4.1.1.15/Glutamate Decarboxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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