| Relationship between functional castration and alpha-fetoprotein produced by hepatoma-bearing female rats. | |
| | |
MedLine Citation:
|
PMID: 76675 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In rats bearing Morris hepatoma No. 7777, serum levels of alpha fetoprotein (AFP) increased as tumour size increased. Hepatoma-bearing females remained in dioestrus once the tumour exceeded a cross-sectional area of 12 cm2. The following changes were seen in tumour-bearing rats compared to control animals: uterine wet weight was significantly decreased, the uterine epithelial mucosa was lower, castration cells developed in the anterior pituitary, and there was a 3- to 23-fold elevation in serum oestrogen levels. We conclude that circulating oestrogen is bound to AFP in hepatoma-bearing female rats and that in this bound state it is unable to exert its normal physiological actions. |
| | |
Authors:
|
T B Pool; N Hagino; I L Cameron |
Related Documents
:
|
7447935 - Different turnover of fucose residues in plasma membranes of rat liver and morris hepat... 163095 - Functional differences in protein synthesis between rat liver trna and trna from noviko... 6652875 - Permanent decrease in activity of ornithine decarboxylase antizyme in rat liver during ... 15739185 - Combined endostatin/sflt-1 antiangiogenic gene therapy is highly effective in a rat mod... 389655 - Age variation in the increase of hypothalamic and brain stem contents of phenylethanola... 17429625 - Preclinical pharmacokinetics and in vitro metabolism of dasatinib (bms-354825): a poten... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of reproduction and fertility Volume: 53 ISSN: 0022-4251 ISO Abbreviation: J. Reprod. Fertil. Publication Date: 1978 May |
Date Detail:
|
Created Date: 1978-06-28 Completed Date: 1978-06-28 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0376367 Medline TA: J Reprod Fertil Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 39-44 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Carcinoma, Hepatocellular / blood*, pathology Estrogens / blood Female Liver Neoplasms / blood*, pathology Neoplasms, Experimental / pathology Organ Size Ovary / pathology, physiopathology* Pituitary Gland, Anterior / ultrastructure Rats Uterus / pathology alpha-Fetoproteins / analysis, physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Estrogens; 0/alpha-Fetoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparative pharmacokinetics of coumarin anticoagulants XXXIII: frequency distribution of dicumarol ...
Next Document: Whipple's disease and ankylosing spondylitis simultaneous occurrence in HLA-B27 positive male.