| Relationship between frontal N-acetylaspartate and cognitive deficits in first-episode schizophrenia. | |
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MedLine Citation:
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PMID: 17507879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim of this study was to evaluate the relationship between N-acetylaspartate (NAA) levels in selected brain regions and cognitive performance in patients with first-episode schizophrenia. MATERIAL/METHODS: Thirty patients (20 male, 10 female; mean age: 22.5 years) with the diagnosis of first-episode schizophrenia and 19 comparable healthy controls were studied. The Wisconsin Card Sorting Test (WCST) was used to assess cognitive functions. MR imaging and MR spectroscopy examinations were performed on a 1.5 T scanner. Voxels of 8 cm3 were positioned in the left frontal lobe, left temporal lobe, and left thalamus. The ratio of NAA to creatine and the ratio of NAA to unsuppressed water signal were analyzed. RESULTS: Patients performed significantly worse than controls on measures of the WCST. In the patient group, NAA levels in the frontal lobe were significantly related to poorer WCST performance. CONCLUSIONS: Cognitive impairment related to dysfunction of the prefrontal cortex in first-episode schizophrenia is associated with NAA level in the frontal lobe. |
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Authors:
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Beata Galińska; Agata Szulc; Eugeniusz Tarasów; Bozena Kubas; Wojciech Dzienis; Leszek Siergiejczyk; Andrzej Czernikiewicz; Jerzy Walecki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medical science monitor : international medical journal of experimental and clinical research Volume: 13 Suppl 1 ISSN: 1643-3750 ISO Abbreviation: Med. Sci. Monit. Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-05-17 Completed Date: 2008-10-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9609063 Medline TA: Med Sci Monit Country: Poland |
Other Details:
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Languages: eng Pagination: 11-6 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Medical University of Białystok, Białystok, Poland. begal@poczta.onet.pl <begal@poczta.onet.pl> |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antipsychotic Agents / therapeutic use Aspartic Acid / analogs & derivatives*, metabolism Cognition Disorders / etiology*, metabolism, pathology, physiopathology* Female Frontal Lobe / anatomy & histology, metabolism*, physiopathology* Humans Male Neuropsychological Tests Schizophrenia / complications*, drug therapy, pathology, physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 56-84-8/Aspartic Acid; 997-55-7/N-acetylaspartate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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