Document Detail

Relationship between frontal N-acetylaspartate and cognitive deficits in first-episode schizophrenia.
MedLine Citation:
PMID:  17507879     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The aim of this study was to evaluate the relationship between N-acetylaspartate (NAA) levels in selected brain regions and cognitive performance in patients with first-episode schizophrenia. MATERIAL/METHODS: Thirty patients (20 male, 10 female; mean age: 22.5 years) with the diagnosis of first-episode schizophrenia and 19 comparable healthy controls were studied. The Wisconsin Card Sorting Test (WCST) was used to assess cognitive functions. MR imaging and MR spectroscopy examinations were performed on a 1.5 T scanner. Voxels of 8 cm3 were positioned in the left frontal lobe, left temporal lobe, and left thalamus. The ratio of NAA to creatine and the ratio of NAA to unsuppressed water signal were analyzed. RESULTS: Patients performed significantly worse than controls on measures of the WCST. In the patient group, NAA levels in the frontal lobe were significantly related to poorer WCST performance. CONCLUSIONS: Cognitive impairment related to dysfunction of the prefrontal cortex in first-episode schizophrenia is associated with NAA level in the frontal lobe.
Beata Galińska; Agata Szulc; Eugeniusz Tarasów; Bozena Kubas; Wojciech Dzienis; Leszek Siergiejczyk; Andrzej Czernikiewicz; Jerzy Walecki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical science monitor : international medical journal of experimental and clinical research     Volume:  13 Suppl 1     ISSN:  1643-3750     ISO Abbreviation:  Med. Sci. Monit.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-17     Completed Date:  2008-10-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9609063     Medline TA:  Med Sci Monit     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  11-6     Citation Subset:  IM    
Department of Psychiatry, Medical University of Białystok, Białystok, Poland. <>
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MeSH Terms
Antipsychotic Agents / therapeutic use
Aspartic Acid / analogs & derivatives*,  metabolism
Cognition Disorders / etiology*,  metabolism,  pathology,  physiopathology*
Frontal Lobe / anatomy & histology,  metabolism*,  physiopathology*
Neuropsychological Tests
Schizophrenia / complications*,  drug therapy,  pathology,  physiopathology*
Reg. No./Substance:
0/Antipsychotic Agents; 56-84-8/Aspartic Acid; 997-55-7/N-acetylaspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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