Document Detail


Relationship between free-radical lipid oxidation and efficiency of coronary angioplasty in coronary patients.
MedLine Citation:
PMID:  18683490     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Low-dose (250 mg daily) oral probucol produces a significant antioxidant effect in coronary patients: increases activity of glutathione peroxidase (enzyme utilizing lipoperoxides) and reduces the content of free-radical oxidation products in the blood. Probucol therapy for 7 days before and for 6 months after coronary angioplasty significantly reduces the severity of coronary artery stenosis.
Authors:
A I Kaminnyi; V Z Lankin; E I Perepelitsa; G G Konovalova; A N Samko; A K Tikhaze; V V Kukharchuk; Yu N Belenkov
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  144     ISSN:  0007-4888     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2008-08-07     Completed Date:  2008-12-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  664-6     Citation Subset:  IM    
Affiliation:
A. L. Myasnikov Institute of Cardiology, Russian Cardiological Center, Russian Ministry of Health, Moscow. akam67@rambler.tu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Angioplasty, Transluminal, Percutaneous Coronary / methods*
Antioxidants / administration & dosage,  therapeutic use
Combined Modality Therapy
Coronary Angiography
Coronary Disease / metabolism,  radiography,  therapy*
Coronary Stenosis / metabolism,  radiography,  therapy
Free Radicals / metabolism*
Glutathione Peroxidase / metabolism
Humans
Lipid Peroxidation / drug effects
Male
Middle Aged
Probucol / administration & dosage,  therapeutic use
Time Factors
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Free Radicals; 23288-49-5/Probucol; EC 1.11.1.9/Glutathione Peroxidase

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