| Relationship between flow and incidence of thrombosis in polytetrafluoroethylene vascular grafts in free microvascular flaps in lambs. | |
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MedLine Citation:
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PMID: 10505441 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have done an experimental study in lambs in which we investigated the influence of flow rate on free microvascular flaps using polytetrafluoroethylene (PTFE) vascular grafts. We set up five surgical groups in which blood flow was progressively increased through the PTFE vascular graft. In group I (venous autograft) we observed just one vascular thrombosis which was located at the site of the anastomosis. In group II (PTFE 3 x 10 mm) all the microvascular flaps became necrosed after the third postoperative day. In group III (PTFE 3 x 10 mm) necrosis also developed in all cases, but the anastomoses remained permeable no longer than eight days. In group IV (3 x 15 mm) the permeability in the microvascular free flaps was about 40% after 21 days, and in group V (3 x 10 mm) it reached 70%. To match graft flow rates with flap survival we did a regression analysis of flow rates for groups II, III, and V and the corresponding survival periods for the flaps. There was a clear and highly significant relationship (r = 0.717, p = 0.0001). In conclusion, it is necessary to maintain blood flow through the prosthesis at a rate higher than the thrombogenic threshold. When the flow rate in the vessels through the PTFE grafts was higher, the viability of the flaps was better. The ideal surgical technique should always be based on an arteriovenous fistula distal to the PTFE vascular graft. It is necessary to maintain blood flow through a prosthesis at a rate higher than the thrombogenic threshold. |
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Authors:
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V Paloma; J M Lasso; A Bazán; J M Serra |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Scandinavian journal of plastic and reconstructive surgery and hand surgery / Nordisk plastikkirurgisk forening [and] Nordisk klubb for handkirurgi Volume: 33 ISSN: 0284-4311 ISO Abbreviation: Scand J Plast Reconstr Surg Hand Surg Publication Date: 1999 Sep |
Date Detail:
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Created Date: 1999-10-26 Completed Date: 1999-10-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8707869 Medline TA: Scand J Plast Reconstr Surg Hand Surg Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 287-94 Citation Subset: IM |
Affiliation:
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Clínica Universitaria de Navarra, Pamplona, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity Blood Vessel Prosthesis* / adverse effects Blood Vessel Prosthesis Implantation Laser-Doppler Flowmetry Microsurgery / adverse effects, methods Necrosis Polytetrafluoroethylene Regression Analysis Sheep Statistics, Nonparametric Surgical Flaps / adverse effects, blood supply*, pathology Thrombosis / blood, etiology* |
| Chemical | |
Reg. No./Substance:
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9002-84-0/Polytetrafluoroethylene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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