| Relationship between fetal pulmonary maturity assessment and neonatal outcome in premature rupture of the membranes at 32-34 weeks' gestation. | |
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MedLine Citation:
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PMID: 11733861 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The absence of fetal pulmonary maturity in patients with preterm premature rupture of the membranes (PPROM) is often considered an indication for conservative management. The purpose of this study was to examine the value of biochemical pulmonary maturity assessment for the prediction of neonatal outcome in patients with PPROM between 32 and 34 weeks' gestation. Pregnancies complicated by PPROM at 32 to 34 weeks' gestation that delivered from January 1995 to May 2000 and had biochemical pulmonary maturity assessment were reviewed. Patients with medical disorders, multiple gestations, fetal growth restriction or structural anomalies, or evidence of intra-amniotic infection were excluded. Neonatal outcome measures were compared between patients with mature and immature pulmonary indices. During this time period, 244 patients with PPROM at 32-34 weeks' gestation were delivered; 78 patients met inclusion criteria (n = 41 patients with mature indices and n = 37 patients with immature indices). There were no cases of perinatal death or sepsis. There was no difference in major neonatal morbidities including need for mechanical ventilation, grade 2 or 3 necrotizing enterocolitis, grade 3 or 4 intraventricular hemorrhage, or seizures. After controlling for confounding factors including gestational age at PPROM and delivery, latency period, group B streptococcus (GBS) vaginal colonization, corticosteroid therapy, neonatal sex, mode of delivery, fetal indications for delivery, and umbilical cord pH, biochemical pulmonary maturity was not predictive of major neonatal morbidity. In our population, biochemical pulmonary maturity status does not appear to be predictive of neonatal morbidity in pregnancies complicated by PPROM at 32-34 weeks' gestation. |
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Authors:
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J S Refuerzo; S C Blackwell; H M Wolfe; S S Hassan; Y Sorokin; S M Berry |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of perinatology Volume: 18 ISSN: 0735-1631 ISO Abbreviation: Am J Perinatol Publication Date: 2001 Dec |
Date Detail:
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Created Date: 2001-12-04 Completed Date: 2002-01-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8405212 Medline TA: Am J Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 451-8 Citation Subset: IM |
Affiliation:
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Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan 48201, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Confounding Factors (Epidemiology) Female Fetal Membranes, Premature Rupture / embryology* Fetal Organ Maturity Gestational Age Humans Infant, Newborn Lung / embryology* Male Pregnancy Pregnancy Outcome* Pregnancy Trimester, Third Respiration, Artificial Retrospective Studies Sensitivity and Specificity |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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