| Relationship between the fatty acid composition of rat lymphocytes and immune functions. | |
| | |
MedLine Citation:
|
PMID: 10884721 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effects of dietary lipids on the fatty acid composition, activation and proliferation of lymphocytes were investigated. Weanling male Wistar rats were fed for 8 weeks on one of two low-fat diets which contained 50 g lipid/kg, or one of two high-fat diets containing 200 g lipid/kg, from either coconut oil or soyabean oil. The fatty acid composition of phospholipids from splenocyte membranes was affected by dietary lipid manipulation, and these differences influenced lymphocyte functions. Increased levels of linoleic acid in spleen lymphocytes correlated negatively with interleukin-2 receptor alpha-chain expression determined either by measuring the mean fluorescence or by the proportion of cells staining positive for CD25, and with the cell proliferation index. However, we found a positive correlation between interleukin-2 receptor alpha-chain expression determined by measuring the mean fluorescence and the cell proliferation index with the oleic acid concentration of spleen lymphocytes. Since phospholipid hydrolysis occurs early in lymphocyte activation, immunosuppressive effects induced by polyunsaturated fatty acids, described in the literature, could be due to an increase of linoleic acid or a decrease of oleic acid affecting many components of plasma-membrane-associated events involved in lymphocyte activation. |
| | |
Authors:
|
M Moussa; J Tkaczuk; J Ragab; J Garcia; M Abbal; E Ohayon; J Ghisolfi; J P Thouvenot |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The British journal of nutrition Volume: 83 ISSN: 0007-1145 ISO Abbreviation: Br. J. Nutr. Publication Date: 2000 Mar |
Date Detail:
|
Created Date: 2000-07-17 Completed Date: 2000-07-17 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 327-33 Citation Subset: IM |
Affiliation:
|
Group d'Etudes en Nutrition Infantile, Laboratoire de Biochimie, CHU Purpan, Toulouse, France. moussa.m@chu-toulouse.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Dietary Fats / administration & dosage, pharmacology* Linoleic Acid / metabolism* Lymphocyte Activation / drug effects Lymphocytes / chemistry, drug effects*, physiology Male Membrane Lipids / chemistry Oleic Acid / metabolism* Phospholipids / chemistry, physiology Rats Rats, Wistar Receptors, Interleukin-2 / drug effects, metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Dietary Fats; 0/Membrane Lipids; 0/Phospholipids; 0/Receptors, Interleukin-2; 112-80-1/Oleic Acid; 2197-37-7/Linoleic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ontogeny of the expression of leptin and its receptor in the murine fetus and placenta.
Next Document: Localization of breast lesions shown only on MRI--a review for the UK Study of MRI Screening for Bre...