Document Detail

Relationship between the extent of coronary artery disease and indicators of free radical activity.
MedLine Citation:
PMID:  1551264     Owner:  NLM     Status:  MEDLINE    
Clinical studies have demonstrated that patients with coronary artery disease (CAD) have markers suggestive of increased free radical (FR) activity when compared with normal subjects; however, the relationship between the extent of CAD and level of FR markers is not known. The following indices of FR activity, plasma malondialdehyde (MDA), plasma thiols (PSH), red blood cell (RBC) glutathione (GSH), and RBC superoxide dismutase (SOD) were measured in 58 patients admitted for coronary angiography and in 50 matched controls. Regression analysis demonstrated no significant correlation between MDA, PSH, GSH, or SOD, and the angiographic grade which indicated the severity of the CAD. Patients with angiographically proven CAD (median 7.9 nmol/ml IQR 6.9-9.2) and patients with a history suggestive of angina pectoris but normal coronary angiograms (median 8.4 nmol/ml IQR 7.4-9.9) had significantly raised MDA levels compared with the controls (median 6.85 nmol/ml IQR 6.1-7.4), p less than 0.001 and p less than 0.005, respectively. The patients with angiographically proven CAD had significantly lower GSH levels (median 1461 microM IQR 1348-1709, p less than 0.002) compared with the controls (median 1754 microM IQR 1492-1930). Significantly raised SOD levels also were detected in patients with angiographically proven CAD (median 121.8 U/ml RBC, IQR 113.8-143.9) and in patients with a history of suggestive of angina pectoris but normal coronary angiograms (median 146 U/ml RBC, IQR 96.8-156.7) when compared with controls (median 96.3 U/ml RBC, IQR 82.4-115.6), p less than 0.001 and p less than 0.02, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
A B Bridges; N A Scott; T H Pringle; G P McNeill; J J Belch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical cardiology     Volume:  15     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-04-28     Completed Date:  1992-04-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  169-74     Citation Subset:  IM    
Department of Medicine, Ninewells Hospital and Medical School, Dundee, Scotland.
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MeSH Terms
Angina Pectoris / blood
Cholesterol / blood
Coronary Disease / blood*
Free Radicals / metabolism
Glutathione / blood*
Malondialdehyde / blood*
Middle Aged
Sulfhydryl Compounds / blood*
Superoxide Dismutase / blood
Reg. No./Substance:
0/Free Radicals; 0/Sulfhydryl Compounds; 542-78-9/Malondialdehyde; 57-88-5/Cholesterol; 70-18-8/Glutathione; EC Dismutase
Comment In:
Clin Cardiol. 1992 Sep;15(9):706-7   [PMID:  1395209 ]

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