| Relationship between the extent of coronary artery disease and indicators of free radical activity. | |
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MedLine Citation:
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PMID: 1551264 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clinical studies have demonstrated that patients with coronary artery disease (CAD) have markers suggestive of increased free radical (FR) activity when compared with normal subjects; however, the relationship between the extent of CAD and level of FR markers is not known. The following indices of FR activity, plasma malondialdehyde (MDA), plasma thiols (PSH), red blood cell (RBC) glutathione (GSH), and RBC superoxide dismutase (SOD) were measured in 58 patients admitted for coronary angiography and in 50 matched controls. Regression analysis demonstrated no significant correlation between MDA, PSH, GSH, or SOD, and the angiographic grade which indicated the severity of the CAD. Patients with angiographically proven CAD (median 7.9 nmol/ml IQR 6.9-9.2) and patients with a history suggestive of angina pectoris but normal coronary angiograms (median 8.4 nmol/ml IQR 7.4-9.9) had significantly raised MDA levels compared with the controls (median 6.85 nmol/ml IQR 6.1-7.4), p less than 0.001 and p less than 0.005, respectively. The patients with angiographically proven CAD had significantly lower GSH levels (median 1461 microM IQR 1348-1709, p less than 0.002) compared with the controls (median 1754 microM IQR 1492-1930). Significantly raised SOD levels also were detected in patients with angiographically proven CAD (median 121.8 U/ml RBC, IQR 113.8-143.9) and in patients with a history of suggestive of angina pectoris but normal coronary angiograms (median 146 U/ml RBC, IQR 96.8-156.7) when compared with controls (median 96.3 U/ml RBC, IQR 82.4-115.6), p less than 0.001 and p less than 0.02, respectively.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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A B Bridges; N A Scott; T H Pringle; G P McNeill; J J Belch |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical cardiology Volume: 15 ISSN: 0160-9289 ISO Abbreviation: Clin Cardiol Publication Date: 1992 Mar |
Date Detail:
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Created Date: 1992-04-28 Completed Date: 1992-04-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 169-74 Citation Subset: IM |
Affiliation:
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Department of Medicine, Ninewells Hospital and Medical School, Dundee, Scotland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angina Pectoris / blood Cholesterol / blood Coronary Disease / blood* Female Free Radicals / metabolism Glutathione / blood* Humans Male Malondialdehyde / blood* Middle Aged Sulfhydryl Compounds / blood* Superoxide Dismutase / blood |
| Chemical | |
Reg. No./Substance:
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0/Free Radicals; 0/Sulfhydryl Compounds; 542-78-9/Malondialdehyde; 57-88-5/Cholesterol; 70-18-8/Glutathione; EC 1.15.1.1/Superoxide Dismutase |
| Comments/Corrections | |
Comment In:
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Clin Cardiol. 1992 Sep;15(9):706-7
[PMID:
1395209
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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