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Relationship between epicardial fat and coronary microvascular dysfunction.
MedLine Citation:
PMID:  24293145     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Coronary microvascular dysfunction (CMVD) is often suggested in patients with typical chest pain and abnormal stress test results that are indicative of myocardial ischemia, in who coronary angiography fails to show fixed stenosis in epicardial coronary arteries. The efficacy of : pharmacologic treatment on the clinical outcome remains to be determined.
AIM: to determine the relationship between CMVD and epicardial fat thickness.
METHODS: A case-controlled study was conducted on 124 patients, aged 40 to 91 years old. A matched set of 62 symptomatic and 62 asymptomatic patients underwent an exercise ECG and transthoracic echocardiography. Coronary angiography was performed in patients with abnormal exercise test results. Patients without coronary artery disease (CAD) were considered for the study. Epicardial fat thickness (EFT) was measured by transthoracic echocardiography in all patients.
RESULTS: EFT was significantly higher in patients with positive exercise test results (but normal epicardial coronary arteries) compared to patients with negative exercise test results (P-value < 0.001). Additionally, the HDL-Cholesterol level was significantly lower in patients with positive exercise test results (but normal epicardial coronary arteries) compared to patients with negative exercise test results (P-value < 0.0001).
CONCLUSION: Patients with increased EFT are at an increased risk for developing angina, recurrent hospitalization and adverse outcomes, even with normal epicardial coronary arteries.
Authors:
Mohammd Sadegh Parsaei; Maryam Nabati; Jamshid Yazdani; Babak Bagheri; Ali Ghaemian; Naser Saffar
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-12-02
Journal Detail:
Title:  Kardiologia polska     Volume:  -     ISSN:  0022-9032     ISO Abbreviation:  Kardiol Pol     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-12-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376352     Medline TA:  Kardiol Pol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Cardiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. dr.mr.nabati@gmail.com.
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