Document Detail

Relationship between endothelial function in the coronary and brachial arteries.
MedLine Citation:
PMID:  16274093     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Endothelial dysfunction is the first step in the progression to atherosclerosis, but little is known regarding whether there is a correlation in endothelial function between the coronary and peripheral arteries. HYPOTHESIS: We investigated the relationship between coronary and peripheral endothelial function. METHODS: In 41 patients (mean age 63 years; 23 men, 18 women) with angiographically normal coronary arteries, changes in brachial artery diameter in response to hyperemic flow and sublingual nitroglycerin (NTG) were measured by high-resolution ultrasonography. During coronary angiography, acetylcholine (ACh, 3 and 30 microg/min) and NTG were infused into the left coronary ostium. The diameter of the coronary artery was quantitatively measured and coronary blood flow (CBF) was calculated by quantitative angiography and Doppler flow velocity measurements. Changes in these parameters in response to each drug infusion were expressed as the percent change from the baseline values. RESULTS: Flow-mediated dilation (FMD) of the brachial artery was 5.0 +/- 3.5% and correlated positively not only with the change in coronary diameter (ACh at 30 microg/min, r = 0.31, p < 0.05) but also with the change in CBF (ACh at 3 microg/min, r = 0.39, p < 0.05; ACh at 30 microg/min, r = 0.46, p < 0.01). Multivariate analysis demonstrated that FMD was one of the factors associated with the changes in coronary diameter and CBF. CONCLUSIONS: These results suggest that brachial endothelial function is associated with coronary endothelial function in patients with angiographically normal coronary arteries, suggesting that impairment of endothelial function may occur simultaneously in both coronary and peripheral arteries.
Hiroki Teragawa; Kentaro Ueda; Keiji Matsuda; Masashi Kimura; Yukihito Higashi; Tetsuya Oshima; Masao Yoshizumi; Kazuaki Chayama
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical cardiology     Volume:  28     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-11-08     Completed Date:  2006-02-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  460-6     Citation Subset:  IM    
Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Japan.
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MeSH Terms
Acetylcholine / administration & dosage
Blood Flow Velocity / drug effects
Brachial Artery / physiopathology*,  radiography,  ultrasonography
Coronary Angiography
Coronary Artery Disease / diagnosis,  physiopathology
Coronary Circulation / drug effects
Coronary Vessels / physiopathology*,  ultrasonography
Dose-Response Relationship, Drug
Endothelium, Vascular / physiopathology*,  radiography
Middle Aged
Multivariate Analysis
Regression Analysis
Risk Factors
Ultrasonography, Interventional
Vasodilation / drug effects
Vasodilator Agents / administration & dosage
Reg. No./Substance:
0/Vasodilator Agents; 51-84-3/Acetylcholine

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