| Relationship between endothelial function and fibrinolysis in early hypertension. | |
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MedLine Citation:
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PMID: 9453323 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Abnormalities in fibrinolysis, endothelial function, and glucose and lipid metabolism have been reported in hypertension. This study was conducted to examine the interrelationships between fibrinolytic factors, glucose and lipid metabolism, and endothelial function in hypertension. The effects of administering an angiotensin converting enzyme inhibitor, benazepril, were also examined. Blood levels of the following substances were measured in patients with borderline and mild hypertension (n=50, 51+/-19 years) and in age-matched controls (n=10): total cholesterol, triglycerides, tissue plasminogen activator activity and antigen, and plasminogen activator inhibitor type 1 activity and antigen. Insulin sensitivity was assessed by oral glucose tolerance test, and endothelial function was assessed by evaluating changes in diameter of the brachial artery during reactive hyperemia as observed by ultrasonography. Activities of tissue plasminogen activator and plasminogen activator inhibitor type 1 were both elevated in the hypertensive patients. Stepwise multiple regression analysis showed that plasminogen activator inhibitor type 1 antigen correlated with insulin sensitivity, total cholesterol levels, and triglycerides levels (P<.01). Endothelial function was negatively correlated with tissue plasminogen activator activity and antigen (P<.01). The chronic administration of benazepril (5-10 mg/d) for 20 weeks improved insulin sensitivity, endothelial function (6.6+/-3.4-->9.0+/-2.5%, P<.01), and tissue plasminogen activator activity and antigen. These results indicate that abnormalities in fibrinolysis are associated with endothelial dysfunction as well as disorders of glucose and lipid metabolism in patients with borderline and mild hypertension. The treatment of such patients with benazepril appeared to improve the impairment in fibrinolysis and endothelial dysfunction. |
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Authors:
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H Tomiyama; Y Kimura; H Mitsuhashi; T Kinouchi; H Yoshida; T Kushiro; N Doba |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hypertension Volume: 31 ISSN: 0194-911X ISO Abbreviation: Hypertension Publication Date: 1998 Jan |
Date Detail:
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Created Date: 1998-02-20 Completed Date: 1998-02-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 321-7 Citation Subset: IM |
Affiliation:
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The Third Department of Internal Medicine, Teikyo University School of Medicine, Ichihara Hospital, Chiba, Japan. h-tomiya@med.teikyo-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amlodipine / therapeutic use Angiotensin-Converting Enzyme Inhibitors / therapeutic use* Benzazepines / therapeutic use* Blood Pressure / drug effects Brachial Artery Calcium Channel Blockers / therapeutic use Carotid Arteries / ultrasonography Cholesterol / blood Echocardiography Endothelium, Vascular / physiology, physiopathology* Female Fibrinolysis* Glucose Tolerance Test Hemostasis Humans Hyperemia Hypertension / drug therapy, physiopathology*, ultrasonography Insulin / physiology Male Middle Aged Plasminogen Activator Inhibitor 1 / blood Reference Values Regression Analysis Tissue Plasminogen Activator / blood Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Benzazepines; 0/Calcium Channel Blockers; 0/Plasminogen Activator Inhibitor 1; 0/Triglycerides; 11061-68-0/Insulin; 57-88-5/Cholesterol; 86541-75-5/benazepril; 88150-42-9/Amlodipine; EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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