Document Detail


Relationship between elevated serum gamma-glutamyltransferase activity and slow coronary flow.
MedLine Citation:
PMID:  19553739     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: We evaluated the relationship between coronary blood flow and serum gamma-glutamyltransferase (GGT) activity in patients with slow coronary flow (SCF). STUDY DESIGN: The study included 90 patients (47 men, 43 women; mean age 50.8+/-9.4 years) with SCF and 88 patients (45 men, 43 women; mean age 51.4+/-8.8 years) with coronary artery disease (CAD), whose diagnoses were made by coronary angiography. Patients with CAD had normal coronary flow. Coronary flow was quantified using the corrected TIMI frame count (TFC) method and serum levels of gamma-glutamyltransferase were measured. The results were compared with those of a control group consisting of 86 age- and sex-matched patients who had normal coronary arteries and normal coronary flow. RESULTS: The three groups were similar with respect to body mass index, presence of hypertension and diabetes mellitus, lipid profiles, and fasting glucose. The use of medications was significantly more common in the CAD group (p<0.01). Compared to the control group, serum GGT activity was significantly increased in both SCF and CAD groups (p<0.01), but these two groups did not differ significantly in this respect (p=0.71). The TFCs for all the epicardial coronary arteries and the mean TFC were significantly higher in the SCF group (p<0.01). Patients with CAD and the controls had similar TFC parameters. The mean TFC showed a positive and moderate correlation with serum GGT activity (r=0.326; p<0.001). In regression analysis, serum GGT activity was found as the only independent predictor of the mean TFC (beta=0.309; p<0.001). CONCLUSION: We have shown for the first time an association between increased serum GGT activity and SCF. Further clinical studies are needed to clarify the physiopathologic role of serum GGT activity in SCF.
Authors:
Nihat Sen; Mehmet F Ozlü; Nurcan Başar; Firat Ozcan; Omer Güngör; Osman Turak; Ozgül Malçok; Kumral Cağli; Orhan Maden; Ali R Erbay; Ahmet D Demir
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Türk Kardiyoloji Derneği arşivi : Türk Kardiyoloji Derneğinin yayın organıdır     Volume:  37     ISSN:  1016-5169     ISO Abbreviation:  Turk Kardiyol Dern Ars     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-06-25     Completed Date:  2010-04-27     Revised Date:  2010-08-10    
Medline Journal Info:
Nlm Unique ID:  9426239     Medline TA:  Turk Kardiyol Dern Ars     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  168-73     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Türkiye Yüksek Ihtisas Heart-Education and Research Hospital, Ankara, Turkey. nihatdrsen@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Agonists / therapeutic use
Adult
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Aspirin / therapeutic use
Body Mass Index
Calcium Channel Blockers / therapeutic use
Coronary Artery Disease / blood*,  drug therapy,  enzymology
Coronary Circulation / physiology*
Female
Heart Rate
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
Male
Middle Aged
Sex Characteristics
gamma-Glutamyltransferase / blood*
Chemical
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Calcium Channel Blockers; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 50-78-2/Aspirin; EC 2.3.2.2/gamma-Glutamyltransferase
Comments/Corrections
Comment In:
Turk Kardiyol Dern Ars. 2009 Jul;37(5):362-3; author reply 363-4   [PMID:  19875918 ]
Turk Kardiyol Dern Ars. 2009 Jul;37(5):361-2   [PMID:  19875917 ]

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