| Relationship between development of fibrosis and hemodynamic changes of the pancreas in dogs. | |
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MedLine Citation:
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PMID: 7239124 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies were conducted to investigate the relationship between development of fibrosis and hemodynamic changes in the pancreas in dogs. The basal blood flow rate in the atrophied, fibrotic pancreas was preserved at almost the same level as in the normal pancreas. Fibrotic pancreas responded to VIP with increased blood flow, but not to administration of secretin. On the other hand, normal pancreas showed a brisk increase of blood flow in response to both of these agents. Our findings suggest that direct arterial acinar blood flow per gram of acini decreases prominently, whereas direct arterial flow to the islets per gram of islet is well maintained after the development of pancreatic fibrosis. It is also suggested that secretin acts indirectly by stimulating metabolic activity of the acinar cells with a secondary increase in blood flow, whereas VIP has a direct effect on the pancreatic vasculature. |
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Authors:
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K Inoue; T Kawano; K Shima; T K Suzuki; T Tobe; H Yajima |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Gastroenterology Volume: 81 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1981 Jul |
Date Detail:
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Created Date: 1981-08-10 Completed Date: 1981-08-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 37-47 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure Dogs Female Hemodynamics* Male Pancreas / blood supply*, pathology, physiopathology Pancreatic Diseases / physiopathology* Regional Blood Flow Secretin / pharmacology Vasoactive Intestinal Peptide / pharmacology |
| Chemical | |
Reg. No./Substance:
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1393-25-5/Secretin; 37221-79-7/Vasoactive Intestinal Peptide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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