| Relationship between decrease in ambulatory blood pressure and heart rate variability due to the effects of taking olmesartan medoxomil. | |
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MedLine Citation:
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PMID: 19301939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUNDS AND METHODS: A higher degree of clinical efficacy with olmesartan compared with other angiotensin receptor blockers, has been reported by several sources. In this study of 31 examples of cases of essential hypertension, Holter electrocardiogram, ambulatory blood pressure monitoring and pulse wave velocity (PWV) measurements were performed before and after substituting olmesartan 20 mg for candesartan 8 mg antihypertensive drug therapy. RESULTS: Following the therapeutic change, daily average systolic and diastolic blood pressures were decreased by 6.7 +/- 9.3 mmHg and 3.6 +/- 8.3 mmHg, respectively, with olmesartan 20 mg; PWV was also significantly decreased. Holter electrocardiogram heart rate variability spectral analysis demonstrated that none of the very low frequency (VLF), high frequency (HF) and low frequency (LF)/HF components were significantly altered. However, a significant correlation was observed between the LF/HF component and blood pressure difference, when blood pressure and heart rate variability components in each individual case were studied. CONCLUSION: This study shows that olmesartan has a stronger antihypertensive effect in comparison to candesartan, and does not generate reflex sympathoexcitatory activity. |
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Authors:
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Taiji Furukawa; Taketo Hatsuno; Yasunari Ueno; Kensuke Nagaoka; Yuji Watari; Takeshi Yamakawa; Toshio Sagawa; Takaaki Isshiki |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Clinical drug investigation Volume: 29 ISSN: 1173-2563 ISO Abbreviation: Clin Drug Investig Publication Date: 2009 |
Date Detail:
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Created Date: 2009-03-23 Completed Date: 2009-05-14 Revised Date: 2011-01-11 |
Medline Journal Info:
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Nlm Unique ID: 9504817 Medline TA: Clin Drug Investig Country: New Zealand |
Other Details:
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Languages: eng Pagination: 257-64 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, School of Medicine, Teikyo University, Teikyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angiotensin II Type 1 Receptor Blockers / therapeutic use* Benzimidazoles / therapeutic use* Biphenyl Compounds / therapeutic use* Blood Pressure / drug effects*, physiology Blood Pressure Monitoring, Ambulatory Dose-Response Relationship, Drug Drug Administration Schedule Electrocardiography Female Heart Rate / drug effects*, physiology Humans Hypertension / drug therapy*, physiopathology Imidazoles / therapeutic use* Japan Male Tetrazoles / therapeutic use* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin II Type 1 Receptor Blockers; 0/Benzimidazoles; 0/Biphenyl Compounds; 0/Imidazoles; 0/Tetrazoles; 144689-24-7/olmesartan medoxomil; 145040-37-5/candesartan cilexetil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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