| Relationship between critical pressure and volume exhaled during negative pressure in awake subjects with sleep-disordered breathing. | |
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MedLine Citation:
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PMID: 20139226 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Critical pressure (Pcrit) is considered a reliable parameter to evaluate the mechanical properties of the passive upper airway (UA) and is significantly increased in patients with obstructive sleep apnea-hypopnea (OSAH) compared with normal subjects. The volume exhaled in the first 0.5 s after application at the mouth of 5 cm H(2)O negative pressure at the onset of expiration (V,NEP(0.5)) during wakefulness has been used as a marker of UA collapsibility. The aim of this study was to investigate if there is a significant relationship between V,NEP(0.5) and Pcrit in normal subjects, snorers, and patients with OSAH. METHODS: Thirty men, 10 with OSAH (aged 64 +/- 9.1 years, BMI 32 +/- 4.9 kg/m(2), apnea-hypopnea index [AHI] 43.8 +/- 24, neck circumference 46.6 +/- 3.7 cm), 10 snorers (aged 68 +/- 11 years, BMI 26.6 +/- 4.6 kg/m(2), AHI 3.5 +/- 0.8, snoring time > or = 30% of sleep time, neck circumference 42.2 +/- 3.9 cm), and 10 controls (aged 67 +/- 12 years, BMI 25.4 +/- 2.2 kg/m(2), AHI 1.9 +/- 1.2, neck circumference 41.2 +/- 2.2 cm) underwent V,NEP(0.5) measurement in supine position while awake and Pcrit measurement during sleep. Correlation between V,NEP(0.5) and Pcrit was performed in all subjects. RESULTS: Controls had V,NEP(0.5) of 456 +/- 82 mL and Pcrit of -1.38 +/- 0.6 cm H(2)O, snorers had V,NEP(0.5) of 321 +/- 33 mL and Pcrit -0.55 +/- 0.3 cm H(2)O, and patients with OSAH showed V,NEP(0.5) of 295 +/- 67 mL and Pcrit of 0.99 +/- 1 cm H(2)O (P < .001 vs normal subjects). A strong correlation was found between V,NEP(0.5) and Pcrit (r(2) = 0.61, P < .0001). CONCLUSIONS: In males with neck circumference > 37 cm, V,NEP(0.5) during wakefulness strongly reflects Pcrit in a wide range of values. Our findings suggest that V,NEP(0.5) can be used as valuable substitute for Pcrit to assess UA collapsibility for clinical and research purposes in these subjects. |
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Authors:
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Luigi Taranto Montemurro; Michela Bettinzoli; Luciano Corda; Alessia Braghini; Claudio Tantucci |
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Publication Detail:
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Type: Journal Article Date: 2010-02-05 |
Journal Detail:
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Title: Chest Volume: 137 ISSN: 1931-3543 ISO Abbreviation: Chest Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-07 Completed Date: 2010-07-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: United States |
Other Details:
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Languages: eng Pagination: 1304-9 Citation Subset: AIM; IM |
Affiliation:
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Cattedra di Malattie dell'Apparato Respiratorio, Spedali Civili, Brescia, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Airway Obstruction / physiopathology Analysis of Variance Body Mass Index Exhalation / physiology* Humans Linear Models Male Middle Aged Neck / anatomy & histology Pharynx / physiopathology* Pressure Respiratory Function Tests Risk Factors Sleep Apnea Syndromes / physiopathology* Snoring / physiopathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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