Document Detail

Relationship between circulating n-3 fatty acid concentrations and endothelial function in early adulthood.
MedLine Citation:
PMID:  11792136     Owner:  NLM     Status:  MEDLINE    
AIMS: Fish consumption is inversely associated with cardiovascular mortality, presumably because of n-3 fatty acids in fish. Whether the protection of n-3 fatty acids extends beyond clinical coronary disease to influence the early vascular biology of atherosclerosis remains unclear. This study determined whether circulating levels of n-3 fatty acids are associated with vascular endothelial function in early adulthood. METHODS AND RESULTS: Three hundred and twenty-six adults (157 males, 169 females, aged 20 to 28 years) had high-resolution ultrasound measurements of flow-mediated brachial artery dilatation (FMD) (endothelium-dependent) and arterial response to glyceryl trinitrate (endothelium-independent). Levels of the n-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid in plasma and erythrocyte membranes of subjects were measured. n-3 Fatty acid levels were not related to vascular function in the whole group. In smokers, however, n-3 fatty acids were positively related to flow-mediated dilatation (plasma DHA vs. FMD: 0.045 mm. %(-1), 95% CI 0.011 to 0.079, P=0.01). Flow-mediated dilatation was also associated with n-3 fatty acid levels in subjects in the top third of the insulin, glucose and triglyceride distributions. CONCLUSION: In young smokers and those with higher fasting insulin, glucose or triglyceride concentrations (factors associated with endothelial dysfunction), n-3 fatty acid levels were positively associated with flow-mediated dilatation. This raises the possibility that physiological levels of circulating n-3 fatty acids may protect the endothelium from early adulthood.
C P M Leeson; A Mann; M Kattenhorn; J E Deanfield; A Lucas; D P R Muller
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European heart journal     Volume:  23     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-01-16     Completed Date:  2002-05-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  England    
Other Details:
Languages:  eng     Pagination:  216-22     Citation Subset:  IM    
Copyright Information:
Copyright 2001 The European Society of Cardiology.
Medical Research Council Childhood Nutrition Research Centre, University College, London, UK.
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MeSH Terms
Blood Circulation / drug effects*,  physiology*
Cardiovascular Diseases / blood,  physiopathology
Cholesterol, HDL / blood,  drug effects
Cholesterol, LDL / blood,  drug effects
Endothelium, Vascular / drug effects*,  physiology*
Erythrocytes / chemistry,  metabolism
Fatty Acids, Omega-3 / blood*,  pharmacology*
Great Britain / epidemiology
Risk Factors
Sex Factors
Smoking / adverse effects
Triglycerides / blood
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Fatty Acids, Omega-3; 0/Triglycerides
Comment In:
Eur Heart J. 2002 Feb;23(3):185-7   [PMID:  11792129 ]

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