| Relationship between circulating levels of RANTES (regulated on activation, normal T-cell expressed, and secreted) and carotid plaque characteristics: the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study. | |
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MedLine Citation:
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PMID: 20943669 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To assess the relationship between regulated on activation, normal T-cell expressed and secreted (RANTES) and carotid atherosclerotic plaque burden and plaque characteristics. METHODS AND RESULTS: Gadolinium-enhanced magnetic resonance imaging (MRI) of the carotid artery was performed in 1901 participants from the Atherosclerosis Risk in Communities (ARIC) Study. Wall thickness and volume, lipid-core volume, and fibrous cap thickness (by MRI) and plasma RANTES levels (by ELISA) were measured. Regression analysis was performed to study the associations between MRI variables and RANTES. Among 1769 inclusive participants, multivariable regression analysis revealed that total wall volume [beta-coefficient (β) = 0.09, P = 0.008], maximum wall thickness (β = 0.08, P = 0.01), vessel wall area (β = 0.07, P = 0.02), mean minimum fibrous cap thickness (β = 0.11, P = 0.03), and high-sensitivity C-reactive protein (β = 0.09, P = 0.01) were positively associated with RANTES. Total lipid-core volume showed positive association in unadjusted models (β = 0.18, P = 0.02), but not in fully adjusted models (β = 0.13, P = 0.09). RANTES levels were highest in Caucasian females followed by Caucasian males, African-American females, and African-American males (P < 0.0001). Statin use attenuated the relationship between RANTES and measures of plaque burden. CONCLUSION: Positive associations between RANTES and carotid wall thickness and lipid-core volume (in univariate analysis) suggest that higher RANTES levels may be associated with extent of carotid atherosclerosis and high-risk plaques. Associations between fibrous cap thickness and RANTES likely reflect the lower reliability estimate for fibrous cap measurements compared with wall volume or lipid-core volume measurements. Statin use may modify the association between RANTES and carotid atherosclerosis. Furthermore, RANTES levels vary by race. |
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Authors:
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Salim S Virani; Vijay Nambi; Ron Hoogeveen; Bruce A Wasserman; Josef Coresh; Franklyn Gonzalez; Lloyd E Chambless; Thomas H Mosley; Eric Boerwinkle; Christie M Ballantyne |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-10-12 |
Journal Detail:
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Title: European heart journal Volume: 32 ISSN: 1522-9645 ISO Abbreviation: Eur. Heart J. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-15 Completed Date: 2011-12-15 Revised Date: 2012-02-01 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: England |
Other Details:
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Languages: eng Pagination: 459-68 Citation Subset: IM |
Affiliation:
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Michael E. DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Methodist DeBakey Heart and Vascular Center, Houston, TX 77030, USA. virani@bcm.tmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged C-Reactive Protein / metabolism Carotid Artery, Common / pathology* Carotid Artery, Internal / pathology* Carotid Stenosis / ethnology, etiology, pathology* Chemokine CCL5 / metabolism* Cohort Studies Enzyme-Linked Immunosorbent Assay Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use Lipids / analysis Magnetic Resonance Angiography Male Middle Aged Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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N01-HC-55015/HC/NHLBI NIH HHS; N01-HC-55016/HC/NHLBI NIH HHS; N01-HC-55018/HC/NHLBI NIH HHS; N01-HC-55019/HC/NHLBI NIH HHS; N01-HC-55020/HC/NHLBI NIH HHS; N01-HC-55021/HC/NHLBI NIH HHS; N01-HC-55022/HC/NHLBI NIH HHS; U01HL075572/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/CCL5 protein, human; 0/Chemokine CCL5; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Lipids; 9007-41-4/C-Reactive Protein |
| Comments/Corrections | |
Comment In:
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Eur Heart J. 2011 Feb;32(4):393-5
[PMID:
20961906
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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